Risperidone

Question 1

Indication

Answer 1

Schizophrenia

Question 2

Mechanism of Action

Answer 2

Selectively blocks serotonin and dopamine receptors in the mesocortical tract of the CNS.

Question 3

Contraindications

Answer 3

-Hypersensitivity
-Avoid alcohol

Question 4

Interactions

Answer 4

Antihypertensive medications-increased effects

Carbamazepine, phenobarbital, phenytoin, rifampin-increased risperidone clearance

CNS-additive effect

Dopamine agonists

Question 5

Side Effects

Answer 5

CNS: abnormal coordination, akathisia, confusion, decreased concentration, drooling, dystonia, sleepwalking, TD

CV: palpitations, elevated triglycerides, hypercholesterolemia, orthostatic hypotension

EENT: dry mouth, ear pain, epistaxis, taste alterations, vision changes

ENDO: glucose abnormalities, SIADH

GI: abdominal pain, anorexia, N/V

GU: decreased libido, ejaculatory disorders, priapism, urinary dysfunction

HEME: anemia

MS: myalgia

RESP: dyspnea

SKIN: alopecia, eczema, photosensitivity

Other: flu-like symptoms, weight gain or loss

Question 6

Life-threatening SE

Answer 6

CNS: hypothermia, neuroleptic malignant syndrome, seizures

CV: atrial fibrillation, bradycardia, cardio-pulmonary arrest, A-V block, Q-T prolongation

ENDO: DKA

GI: intestinal obstruction, pancreatitis

HEME: agranulocytosis, bone marrow suppression, TTP

RESP: PE, sleep apnea

Other: anaphylaxis, angioedema