Olanzapine Flashcards
Indication
Schizophrenia
Mechanism of Action
May achieve antipsychotic effects by antagonizing
dopamine and serotonin receptors
Contraindications
-Hypersensitivity
-Avoid alcohol
Interactions
Antihypertensive-increased effects
CNS-depressants-orthostatic hypotension
Dopamine agonists
Fluoxetine-deceased olanzapine clearance
Side Effects
Side Effects
CNS: abnormal gait, akathisia, dizziness, hypertonia, insomnia, motor & sensory instability
CV: HTN, hyperlipidemia, elevated triglyceride levels, peripheral edema
EENT: dry mouth, drooling
GI: abdominal pain, dysphagia
MS: arthralgia
RESP: cough
SKIN: photosensitivity
Other: flu-like-symptoms,
weight gain
Life-threatening SE
CNS: neuroleptic malignant syndrome
suicidal ideation
CV: bradycardia, DVT
ENDO: DKA, hyperprolactinemia
GI: hepatitis, pancreatitis
HEME: agranulocytosis, leukopenia, neutropenia
MS: Rabdo
RESP: PE
SKIN: ecchymosis
Other: anaphylaxis, angioedema, DRESS
