Haloperidol (Haldol)

Question 1

Indication

Answer 1

Psychosis, &
Schizophrenia

Question 2

Mechanism of Action

Answer 2

May block postsynaptic dopamine receptors in the limbic system and increase brain turnover of dopamine

Question 3

Contraindication

Answer 3

Hypersensitivity, Avoid alcohol, Dementia with Lewy bodies

Question 4

Interaction

Answer 4

Alprazolam, buspirone, chlorpromazine, fluoxetine, promethazine, venlafaxine, increase-plasma haloperidol
Benztropine-decreases haloperidol & TD can develop.

Question 5

Side Effects

Answer 5

CNS: agitation, confusion,

CV: hypertension, orthostatic hypotension

EENT: blurred vision, dry mouth

ENDO: breast discomfort, engorgement

GI: cholestasis, N/V

GU: decreased libido, ejaculatory disorder, priapism

HEME: anemia

SKIN: acne, photosensitivity

Other: weight gain or loss

Question 6

Life-threatening SE

Answer 6

CNS: extrapyramidal reactions (may be irreversible), hypothermia, neuroleptic malignant syndrome, seizures

CV: cardiac arrest, QT prolongation, Torsades de point

EENT: laryngeal edema

GI: hepatitis

HEME: agranulocytosis, bone marrow suppression

MS: rhabdomyolysis

SKIN: exfoliative dermatitis

Other: anaphylaxis, angioedema, heatstroke