Risk factors Flashcards
risk factor UDT
4x if unilateral UDT
10 x if bilateral UDT
how many GCT arise in UDT
7-10%
10% of testicular cancer patients history of UDT
family hisotry risk in father/brother
6-8x
4x in father to son
8-10x in brother
risk increase if poor semen
1.6 x
contralateral testicle risk
metchronous risk previous testicular cancer
5-10%
12-18 x risk
klinefelter syndrome kallman
lifetime risk 1:200
risk in males generally
1:250 males
incidence testicular cancer
3-10 /100,000
around 4 in europe
peak age
seminoma
non seminoma
pure seminoma 4th decade i.e. 30s
NSGCT third decade i.e. 20s
Warde nomogram risk factors recurrence stage 1a seminoma
12% no risk factors 16% one risk factor 32% two risk factors rete testis invasion and size >4cm general risk seminoma CS 1 recurrence 19% , generally within 3 years
NSGCT risk factor with/out LVI
with LVI 50% relapse
without 10-20% three year relapse rate
general relapse rate 25-30%
lifetime risk testicular cancer
1:200
age over 60 tumour type
more than half will have lymphoma
tumour type in infants and young boys
yolk sac tumours
risk of devleoping CL testicular cancer in UDT
10% risk developing c/l tc for crytoporchidism
type of testicular cancer with HIV
seminoma
risk of GCNIS developing testicular cancer
50% in 5 years
how many men with TC have oligoospermia
50%
genetic chromosome
iso chromosomes of short arm of chromosome 12
p53 locus alternations
klinefelter
kallman
how many bilateral
1%
how many GCT
> 90%
how many GCT
> 90%
seminoma stage 1
how many confied testis
how many loco regional mets
how many advanced
75%
15%
10%
