Histological types Flashcards
GCT type 1 not GCNIS
pre pubertal yolk sac tumour
GCT type III not GCNIS
spermatocytic tumours
chromosome 9 amplification
met disease very rare
just need radical orchidectomy
GCT type II
post pubertal GCT from GCNIS
seminoma histology
white firm
large clear cytoplasm
NSGCT histology
embryonal cancer, yolk sac, chorio, teratoma, somatic
sex cord stromal tumours
leydig tumours 4% adut testicular cancer, 2.5% have met potential, no association with UDT, gynaecomastia, refractory to chemoradiation
Sertoli - 1% testicular tumour, risk met potential unclear, can have TSS
likllihood presentation of seminoma in CS1
75-80%
liklihood presentation NSGCT in CS 1
55-64%
age 0-5 tumours
teratoma and yolk sac type 1
age 15-30
NSGCT
30-45 age
seminoma
50 plus age
type III
info from pathology report
histological type percentage size rete testis lymphovascular TA and TV and cord involvement GNCIS mutiplicity
testicular epidermoid cyst
onion ring appearance US hypoechoic lesion with hyper echoic margins 1% of all testicular tumours not associated with GCNIS
how many seminoma have raised tumour markers
10%
always bHCG
10% have raised LDH
how many seminoma have raised tumour markers
10%
always bHCG
10% have raised LDH
where do seminoma spread
lower metastatic potential
paraortic region
which type more sensitive radiation
seminoma
how many NSGCT have raised tumours markers
80%
of which 60% will have raised AFP
leydig cell tumours account for how many bilat how many malignant association UDT hormones produces whered spread chemo radiosensitivie
1-3%
3%
10% malgiantn
not asscoiated with UDT
paraneoplastic early virilisation children testosterone gynaecomastic in adults due to oestorgen spread retroperitoneum refractory chemo and radio
what % of TC have contralateral GCNIS
5%
histology of GCNIS
malignant germ cells lining semniferous tubules intact basement membrane nuclear pleomorphism tubules smaller diameter than normal decreased or absent spermatogenesis atypical cells aligned along BM
population incidence of GNIS
0.8%
paper of progression of GNCIS 50%
Harland
