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Testicular Cancer > Histological types > Flashcards

Histological types Flashcards

1
Q

GCT type 1 not GCNIS

A

pre pubertal yolk sac tumour

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2
Q

GCT type III not GCNIS

A

spermatocytic tumours
chromosome 9 amplification
met disease very rare
just need radical orchidectomy

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3
Q

GCT type II

A

post pubertal GCT from GCNIS

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4
Q

seminoma histology

A

white firm

large clear cytoplasm

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5
Q

NSGCT histology

A

embryonal cancer, yolk sac, chorio, teratoma, somatic

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6
Q

sex cord stromal tumours

A

leydig tumours 4% adut testicular cancer, 2.5% have met potential, no association with UDT, gynaecomastia, refractory to chemoradiation
Sertoli - 1% testicular tumour, risk met potential unclear, can have TSS

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7
Q

likllihood presentation of seminoma in CS1

A

75-80%

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8
Q

liklihood presentation NSGCT in CS 1

A

55-64%

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9
Q

age 0-5 tumours

A

teratoma and yolk sac type 1

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10
Q

age 15-30

A

NSGCT

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11
Q

30-45 age

A

seminoma

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12
Q

50 plus age

A

type III

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13
Q

info from pathology report

A 
histological type percentage
size
rete testis
lymphovascular
TA and TV and cord involvement
GNCIS
mutiplicity
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14
Q

testicular epidermoid cyst

A 
onion ring appearance US
hypoechoic lesion
with hyper echoic margins
1% of all testicular tumours
not associated with GCNIS
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15
Q

how many seminoma have raised tumour markers

A

10%
always bHCG
10% have raised LDH

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15
Q

how many seminoma have raised tumour markers

A

10%
always bHCG
10% have raised LDH

16
Q

where do seminoma spread

A

lower metastatic potential

paraortic region

17
Q

which type more sensitive radiation

A

seminoma

18
Q

how many NSGCT have raised tumours markers

A

80%

of which 60% will have raised AFP

19
Q 
leydig cell tumours
account for
how many bilat
how many malignant
association UDT
hormones produces 
whered spread
chemo radiosensitivie
A

1-3%
3%
10% malgiantn
not asscoiated with UDT

paraneoplastic
early virilisation children testosterone
gynaecomastic in adults due to oestorgen
spread retroperitoneum
refractory chemo and radio
20
Q

what % of TC have contralateral GCNIS

A

5%

21
Q

histology of GCNIS

A 
malignant germ cells lining semniferous tubules
intact basement membrane
nuclear pleomorphism
tubules smaller diameter than normal
decreased or absent spermatogenesis
atypical cells aligned along BM
22
Q

population incidence of GNIS

A

0.8%

23
Q

paper of progression of GNCIS 50%

A

Harland

24
Q

treatment of GCNIS

A

radiation 16-20Gy

25
Q

which cancer spread haematogenously

CT head and caution chemo

A

choriocarcinoma
always elevated bHCG but does not produce AFP
always CT head exclude mets
caution chemo as can bleed vascular tumours

Testicular Cancer (9 decks)

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