chemotherapy

Question 1

common side effects chemo

Answer 1

Common from chemotherapy: Anaemia, low PLTS, Neutropaenia + risk opportunistic infections, hair loss, mouth ulcers, diarrhoea, nausea, PE

Question 2

bleomycin

Answer 2

Lung fibrosis, low FiO2 / ventilator pressures with GA

Question 3

cisplatin

Answer 3

Nephrotoxic, Neuropathy (peripheral / deafness), hypertension / cardiovascular

Question 4

etoposide

Answer 4

Metallic taste, rare acute leukaemia

Question 5

action cisplatin

Answer 5

Alkylating agents act directly on DNA, causing cross-linking of DNA strands, abnormal base pairing, or DNA strand breaks, thus preventing the cell from dividing. Alkylating agents are generally considered to be cell cycle phase nonspecific, meaning that they kill the cell in various and multiple phases of the cell cycle

Question 6

gemcitabine mechanism

Answer 6

Interfere with DNA synthesis. They are structural analogs or they inhibit several enzymes. S-phase specific

Question 7

anit tumour antibioticw

Answer 7

Cause linkage of double strands of DNA and prevent replication. They are derived from microorganisms. Cell cycle specific drug

Question 8

etoposide mechanism

Answer 8

DNA Topoisomerases I and II are essential enzymes for transcription, replication and mitosis. The following drugs are able to inhibit these enzymes