Rickets

Question 1

Whats rickets and its features?

Answer 1

Failure in mineralization of the growing bone or osteoid tissue. (Osteomalacia in mature bones)
Clinical features- 10

Question 2

Causes?

Answer 2

1. Nutritional / Iry rickets 7
2. Intestinal malabsorption 3
3. Defective production of 25(OH)D2 -CLD
4. Increased metabolism of 25(OH)D3-enzyme induction by anticonvulsants like phenobarbital
5. defective production of 1,25(OH)2D3-3
6. target organ resistance to 1,25(OH)2D3

Question 3

Diagnosis of rickets?

Answer 3

Low ca,low po43- (but high in renal rickets), ALP high , maybe pth high and vit D low
Xray of the wrist joint- cupping,flaying,osteopenia ,widening of epiphysis