Premature Sexual Development

Question 1

What js premature sexuality development?

Answer 1

Befofe 8 yrs -females
Before 9 yrs - males
Include,
Precocious when it is accompanied by a growth spurt
Premature breast development (thelarche)
Premature pubic hair development (pubarche)

Question 2

Types of precocious puberty?

Answer 2

True/ central PP - GnRH dependent. Premature activation of hypothalamic pitutary gonadal axis
Pseudo/ peripheral PP - without brain involvement, from excess sex steroids

In females this is usually familial
In makes usually uncommon and has an organic cause

Question 3

Ex of testes?

Answer 3

BL enlargement suggest- gnrh release usually from an intracranial lesion
Small testes - adrenal cause ( tumor or adrenal hyperplasia)
UL enlarged testis suggest a gonadal tumor

Question 4

Mx of PP?

Answer 4

Tx the underlying cause
Adress the psychological difficulties
GnRH analogous (eg- goseralin,zoladex) to stop the pulsatile release

Question 5

Isolated thelarche ( breast development)

Answer 5

5

Question 6

Delayed puberty?

Answer 6

Absence of pubertal development by,
Female-14 yrs
Male- 15 yrs

More common in males
Often familial

Question 7

Causes of delay ped puberty?

Answer 7

1.constitutional
2.low GnRH secretion (hypogonadotrophin hypogonadism)
-systemic disease 7
-hypothalmo pitutary disorders 4
-acquired hypothyroidism
3. High gonadotrophin secretion (hyperglnadotrophic hypogonadism)
-chromasomal abnormalities 2
Steroid hormona enzyme deficiency
-acquired gonadal damage 6