Rho_ROCK_Flashcards

Question 1

What downstream targets of Rho kinase are involved in cytoskeletal dynamics?

Answer 1

MLC (Myosin Light Chain), LIM Kinases, ERMs (Ezrin, Radixin, Moesin), Adducin

Question 2

What is the role of MLC in the Rho/ROCK pathway?

Answer 2

Stress fiber assembly and cell contraction

Question 3

How does ROCK regulate nitric oxide production?

Answer 3

By activating eNOS (Endothelial Nitric Oxide Synthase)

Question 4

Which downstream target of Rho kinase is involved in actin-network assembly?

Answer 4

Adducin

Question 5

What is the function of LIM Kinases in the Rho/ROCK pathway?

Answer 5

Actin-filament stabilization

Question 6

What is the role of ERM proteins in the Rho/ROCK pathway?

Answer 6

Actin-membrane linkage

Question 7

Which downstream target of Rho kinase regulates growth cone collapse?

Answer 7

CRMP2 (Collapsin Response Mediator Protein 2)

Question 8

Which downstream target of Rho kinase is involved in cardiomyocyte contraction?

Answer 8

Troponin T

Question 9

How does ROCK affect microtubule stabilization?

Answer 9

By acting on Tau protein

Question 10

What is the role of MLCP in the Rho/ROCK pathway?

Answer 10

Regulates contraction by dephosphorylating MLC