Biotransformation Flashcards
Read on cytochrome P450 enzymes
What type of conjugation is for the removal to toxic electrophilic compounds
Glutathione conjugation
What type of conjugation does acetaminophen mainly go through
Glucuronidation
What type of conjugation can also conjugate compounds that are glucuronidated
Sulfation
What are the two functional n-acetyltransferases in Humans and where can they be found
NAT1- ubiquitously expressed in human tissues
NAT2- found in the liver and GI tract
What food can affect Glucuronidation, ad what specific compound is responsible
Grape juice - polyphenols
What acts as a competitive inhibitor for CYP enzymes
Caffeine
Which CYPS does cirrhosis usually affect
CYP 3A and 1A sub families
WHat is resonsible for the inactivation of Warfarin
CYP2A6
WHat type of reaction is the inactivation of warfarin
Reduction
What is the amino sequwnce of Gluthahione
Gly-Cys-Glu
What CYP does Barbecued meat induce
CYP1A2 and CYP1A1
WHat CYP does eating Broccoli induce
CYP1A2
Which drugs metabolism is accelerated in female epileptics just before Menstraution
Phenytoin
Which drug is metabolised more slowly in women
Ciprofloxacin
Which drugs rate of metabolism is found to be double in smokers than in non smokers
Fluvoxamine
Which CYP is mainly induced by Alcohol
CYP2E1
what is used in phenotyping CYP2D6
Debrisoquine
