Pharmacodynamics Flashcards
What is referred to how a drug works
Mechanism of action of the drug
What is pharmacodynamics
It is the study of the biochemical or physiological effects of drugs, their mechanism of action and the relationship between the dose/concentration and the effect produced
What are the two ways drugs work
Conventional mechanism
Unconventional/ non-specific mechanism
How does the conventional mechanism owrk
They interact with endogenous proteins that are regulatory molecules
Give example of regulatory molecules that the conventional mechanism interact with
Receptors, Enzymes, Ion Channels, Transport Molecules/carriers
How does the unconventional mechanism work
They interact with other molecules apart from regulatory molecules/ proteins
What are the main receptor Drug targets
G-protein coupled receptors
Kinase-linked and related receptors
Ionotropic receptors
Nuclear receptors
how do drugs work on enzymes
By inhibiting the enzyme
Acting as a false substrate
Acting as a prodrug requiring activation from the enzyme
What is the name of the does of a drug that does not give any effect
Subliminal/Subthreshold does
