Rheumatology: Rheumatoid Arthritis Flashcards
RA is a systemic, inflammatory, autoimmune disorder of unknown etiology that results in predominantly _____, symmetric, inflammatory synovitis leading to cartilage and bone destruction and deformities.
peripheral
Which joints does RA typically manifest in?
small joints of the hands and feet EXCEPT the DIPs, C1-C2, crycoartenoid, ossicles of the ear, and TMJ
What are the symptoms of RA?
morning stiffness, soft tissue swelling around joints, pain, deformities, loss of function
What are the signs of RA?
joint warmth and swelling, tenderness to palpation, deformities
What are the serologic findings in RA?
RF present ESR or CRP elevated anemia, hypergammaglobinemia CCP Abs inflammatory (>2000 WBC/microL), mostly neutrophils Low complement and glucose
Name a known risk factor for RA.
smoking
What radiographic findings are seen in RA?
swelling
juxta-articular osteopenia
symmetric loss of joint space
erosions in marginal distribution
What are rheumatoid nodules and how often are they seen?
nodules of extensor surfaces, tendon sheaths, or lungs; 20-25% of those that are RF positive
RA has other end-organ involvement. Where?
eyes (scleritis), lungs (pulm. fibrosis or nodules), pericardium, peripheral nerves (neuropathy)
What is the fem:male ratio of RA?
2.5:1
What allele is associated with RA?
HLA-DR4
RA begins with inflammation in the _____, with later destruction of the articular cartilage, bone, and periarticular structures.
synovium
In the early stages of RA, the synovial fluid is mostly composed of ____ cells.
mononuclear
What is pannus?
an organized mass of granulation tissue consisting of macs, T cells, B cells, and fibroblasts
Which gene is probably the most important for RA?
DRB1 (QKRAA)
