Hemostasis Defects

Question 1

What test will be abnormal in Dysfibrinogenemia?

Answer 1

TCT

Question 2

What test will be abnormal in Hypofibrinogenemia?

Answer 2

fibrinogen

Question 3

What test will be abnormal in Thrombocytopenia?

Answer 3

platelet count

Question 4

What test will be abnormal in Platelet dysfunction?

Answer 4

bleeding time

Question 5

What test will be abnormal in Hemophilia?

Answer 5

PTT

Question 6

What test will be abnormal in Factor VII deficiency?

Answer 6

PT/INR

Question 7

______ can be diagnosed using the platelet count test.

Answer 7

Thrombocytopenia

Question 8

______ can be diagnosed using the bleeding time test.

Answer 8

Platelet dysfunction

Question 9

_____ can be diagnosed via an abnormal PTT test.

Answer 9

Hemophilia

Question 10

_____ can be diagnosed by an abnormal PT/INR test.

Answer 10

factor VII deficiency

Question 11

______ can be diagnosed using the TCT test.

Answer 11

Dysfibrinogenemia

Question 12

_____ can be diagnosed using the fibrinogen test.

Answer 12

Hypofibrinogenemia

Question 13

What is lupus anticoagulant associated with?

Answer 13

thrombosis

Question 14

What is pancytopenia?

Answer 14

low RBCs, WBCs, and platelets

Question 15

If you see mucocutaneous bleeding, think ____. If you see soft tissue, joint, or deep bleeding, think ____.

Answer 15

platelet or vWF defect; coagulpathy

Question 16

If the Epi PFA test is abnormal but the ADP PFA test is normal, think ____.

Answer 16

aspirin effect

Question 17

If the Epi PFA test is abnormal AND the ADP PFA test is ALSO abnormal, think ____.

Answer 17

abnormal platelet function (uremia, low platelet count, Hct low)

Question 18

What is the TT?

Answer 18

thrombin time- measures the procoagulant activity of

fibrinogen and is also very sensitive to the anticoagulant effect of heparin or fibrin split products

Question 19

What is the BT?

Answer 19

bleeding time- measures the platelet and vessel interaction, as well as the number and the function of platelets- not really used anymore but would show low platelet count or vWD

Question 20

What is the PFA?

Answer 20

platelet function analyzer- measures in vivo bleeding time

Question 21

What is the most common presentation of factor XI deficiency?

Answer 21

post-op bleeding

Question 22

What is ristocetin-induced-platelet-aggregation?

Answer 22

a test for vWD to check abnormal platelet aggregations

Question 23

What will abnormal factor VIII inhibitor look like?

Answer 23

abnormal PTT, mixing test that doesn’t correct

Question 24

What findings will be seen in DIC lab tests?

Answer 24

Prolonged PT
Greatly prolonged PTT
Prolonged thrombin time
Low platelet count
Low fibrinogen level
Increased fibrin split products
Increased D-dimer

Question 25

How is lupus anticoagulant found?

Answer 25

abnormal PTT that does not correct; thrombotic syndrome; abnormal dilute Russell’s Viper Venom Test (dRVVT)