Hemostasis Defects Flashcards
What test will be abnormal in Dysfibrinogenemia?
TCT
What test will be abnormal in Hypofibrinogenemia?
fibrinogen
What test will be abnormal in Thrombocytopenia?
platelet count
What test will be abnormal in Platelet dysfunction?
bleeding time
What test will be abnormal in Hemophilia?
PTT
What test will be abnormal in Factor VII deficiency?
PT/INR
______ can be diagnosed using the platelet count test.
Thrombocytopenia
______ can be diagnosed using the bleeding time test.
Platelet dysfunction
_____ can be diagnosed via an abnormal PTT test.
Hemophilia
_____ can be diagnosed by an abnormal PT/INR test.
factor VII deficiency
______ can be diagnosed using the TCT test.
Dysfibrinogenemia
_____ can be diagnosed using the fibrinogen test.
Hypofibrinogenemia
What is lupus anticoagulant associated with?
thrombosis
What is pancytopenia?
low RBCs, WBCs, and platelets
If you see mucocutaneous bleeding, think ____. If you see soft tissue, joint, or deep bleeding, think ____.
platelet or vWF defect; coagulpathy
If the Epi PFA test is abnormal but the ADP PFA test is normal, think ____.
aspirin effect
If the Epi PFA test is abnormal AND the ADP PFA test is ALSO abnormal, think ____.
abnormal platelet function (uremia, low platelet count, Hct low)
What is the TT?
thrombin time- measures the procoagulant activity of
fibrinogen and is also very sensitive to the anticoagulant effect of heparin or fibrin split products
What is the BT?
bleeding time- measures the platelet and vessel interaction, as well as the number and the function of platelets- not really used anymore but would show low platelet count or vWD
What is the PFA?
platelet function analyzer- measures in vivo bleeding time
What is the most common presentation of factor XI deficiency?
post-op bleeding
What is ristocetin-induced-platelet-aggregation?
a test for vWD to check abnormal platelet aggregations
What will abnormal factor VIII inhibitor look like?
abnormal PTT, mixing test that doesn’t correct
What findings will be seen in DIC lab tests?
Prolonged PT Greatly prolonged PTT Prolonged thrombin time Low platelet count Low fibrinogen level Increased fibrin split products Increased D-dimer
How is lupus anticoagulant found?
abnormal PTT that does not correct; thrombotic syndrome; abnormal dilute Russell’s Viper Venom Test (dRVVT)
