Rheumatology Flashcards

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1
Q

Lupus serology

A

ANA
Ds DNA (antismith) Nephritis
Anti-histone drug Induced

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2
Q

RA Serology

A

RF

Anti-ccp

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3
Q

Scleroderma, CREST antibody

A

Anti-centromere

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4
Q

Scleroderma, Systemic Antibody

A

Topoisomerase, Scl70

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5
Q

SLE Presentation

A
4 of 11 for the diagnosis 
Malar rash 
Discoid rash 
Serositis 
Oral Ulcers 
Arthritis 
Photosensitivity 
blood 
Renal Failure 
ANA pos 
Immunologic 
Neuro
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6
Q

SLE Dx Tests

A
Serology-
ds-DNA (anti-smith) nephritis 
Anti-histone-Drug induced 
U/A-ESR, CRP
C3,C4
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7
Q

SLE Tx

A

Everyone-Hydroxychloroquine
Steroids (flare)

Nephritis-
IV cyclophosphamide
Oral Mycophenolate

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8
Q

drugs that induce lupus

A

Hydralazine
Isoniazid
Procainimide
methlydopa

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9
Q

Rheumatoid Arthritis Presentation

A

Morning Stiffness >60 min

Hands/feet affected symmetrical >3 joints spares DIP

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10
Q

RA Treatment

A

NSAIDs for Sx Control
EVERYONE-Methotrexate
Severe (TNF-a Inhibitors)
Steroids for flares

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11
Q

CREST Scleroderma presentation, Dx

A
Calcinosis 
Raynauds
Esophageal dysmotility 
Sclerodactyly 
Telangiectasias 
Dx: Anti-centromere 
Pulmonary Artery HTN
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12
Q

Diffuse Scleroderma Presentation, Dx

A
CREST + Visceral Involvement 
Lung=Interstitial lung disease 
Heart=constrictive pericarditis 
Kidney=renal scleroderma (ACEi)
Dx: ANTI-SCL-70 (topoisomerase)
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13
Q

Scleroderma Treatment

A

Sclerodactyly=Penacillamine
Esophageal=PPI
Raynauds/Calcinosis=CCB

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14
Q

Sjogrens Presentation, Dx, Tx

A
Dry eyes, Dry Mouth, Parotid Swelling 
Dx: ANA, RF serology 
RO and La
Schirmer test 
Tx: Artifical tears, saliva
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15
Q

Idiopathic Inflammatory Myopathy Presentation, Dx, Tx

A
Proximal muscle weakness, Painless, Subacute, malignancy 
heliotrope rash 
Grottens papules-symmetrical 
Shawl Sign 
Dx: Increased CK 
EMG 
Anti Mu, Jo
Tx: Steroids
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16
Q

Arthrocentesis
>50 K WBCs
+ Organism
- Crystal

A
Infection 
Gonorrhea 
Hematogenous, STD 
Cervicitis, Urethritis 
Dx: Gram stain (-) 
NAAT 
Tx: Ceftriaxone 
7-14 days IV 
Doxycycline or azithromycin
17
Q

Non-gonorrhea monoarticular arthropathy

Dx, Tx

A

Dx: Gram stain (+)
Tx: Nafcillin

18
Q

Arthrocentesis

Shows Crystals

A

Gout or pseudo gout

19
Q

Gout Presentation

A

Crystals Negatively Bifringent
Patient history=CKD, EtOH, Thiazide use
presents with podogra

20
Q

Tumor Lysis syndrome Causes, ppx, tx

A

Chemo, leukemia, Renal Failure
ppx: IVF
Allopurinol
Tx: Rasburicase

21
Q

Gout Acute Flare Tx

A

Colchicine
NSAIDs
Steroids

22
Q

Gout Tx >2 attacks/year

A

Lifestyle modifications-alcohol, red meat, fructose
>2 attacks/year - Allopurinol
Febuxostat

23
Q

gout PPX

A

colchicine

24
Q

Repeated Gout Attacks Dx, Tx

A
Uric Acid level, >6
goal <6 
Tx: Lifestyle
Allopurinol 
Febuxostat
25
Q

Gout PPx

A

Colchicine

26
Q

What are the seronegative Arthritides PAIR

A
Psoriatic 
Ankylosing
IBD related 
Reactive 
all are HLA-B27 positive
27
Q

Ankylosing Spondylitis Presentation, Dx, Tx

A
Sacroilieitis - low back pain 
better with use 
Dx: X-ray=Bamboo Spine 
Tx: NSAIDs
Localized Steroids
Anti-TNFa
F/u back pain-CT
28
Q

Psoriatic Arthritis Presentation, Dx, Tx

A
Psoriasis and arthritis 
Nail pitting 
Dx: Clx 
Tx: NSAIDs 
Local steroids 
DMARDs
ANTI-TNFa
29
Q

IBD Related (Enteropathic) Presentation, Dx, Tx

A

IBD and arthritis
Dx: Clx
Tx-Treat the IBD
No NSAIDs/steroids

30
Q

Reactive Arthritis Presentation, Dx, Tx

A
Urethritis and arthritis 
(conjunctivitis->Reiters)
Dx: Arthrocentesis negative 
Find Infxn
Tx: Arthritis=NSAIDs + time 
treat GC/NG
31
Q

Giant Cell Arthritis Presentation, Dx, Tx (Large)

A

Jaw Claudication, Vision Changes, Temporal Tenderness
Dx: Bx
Tx: Steroids

32
Q

Takeyasu Presentation Dx, Tx (Large)

A

<40 Aorta and branches
Pulselessness
Dx: Angiogram
Tx: Steroids

33
Q

Wegners Granulomatosis Presentation, Dx, Tx

small vessel

A

Hemoptysis, Hematuria, something with the nose
Dx: C-ANCA
Bx ( BEST)
Tx: Steroids and cyclophosphamide

34
Q

Polyarteritis Nodosum Presentation, Dx, Tx

A
Associated with Hep B 
Gut, Renal, Skin 
Mesenteric Ischemia 
Renal Failure 
Purpura Mono neuritis Multiplex 
Dx: angiogram 
Tx: Steroids and cyclophosphamide
35
Q

Cryoglobulinemia Presentation, Dx, Tx

A
associated with HepC
Palpable Purpura + HepC 
Tx: Severe-Plasmapheresis
Underlying Dz
Steroids and cyclophosphamide
36
Q

Henoch Scholnein Purpura Presentation, Dx, Tx

A

Palpable Purpura
GI Sx- Pain of bleeding
Dx: Bx-IgA immunofluorescence
Tx: Steroids