Rheumatology Flashcards
Lupus serology
ANA
Ds DNA (antismith) Nephritis
Anti-histone drug Induced
RA Serology
RF
Anti-ccp
Scleroderma, CREST antibody
Anti-centromere
Scleroderma, Systemic Antibody
Topoisomerase, Scl70
SLE Presentation
4 of 11 for the diagnosis Malar rash Discoid rash Serositis Oral Ulcers Arthritis Photosensitivity blood Renal Failure ANA pos Immunologic Neuro
SLE Dx Tests
Serology- ds-DNA (anti-smith) nephritis Anti-histone-Drug induced U/A-ESR, CRP C3,C4
SLE Tx
Everyone-Hydroxychloroquine
Steroids (flare)
Nephritis-
IV cyclophosphamide
Oral Mycophenolate
drugs that induce lupus
Hydralazine
Isoniazid
Procainimide
methlydopa
Rheumatoid Arthritis Presentation
Morning Stiffness >60 min
Hands/feet affected symmetrical >3 joints spares DIP
RA Treatment
NSAIDs for Sx Control
EVERYONE-Methotrexate
Severe (TNF-a Inhibitors)
Steroids for flares
CREST Scleroderma presentation, Dx
Calcinosis Raynauds Esophageal dysmotility Sclerodactyly Telangiectasias Dx: Anti-centromere Pulmonary Artery HTN
Diffuse Scleroderma Presentation, Dx
CREST + Visceral Involvement Lung=Interstitial lung disease Heart=constrictive pericarditis Kidney=renal scleroderma (ACEi) Dx: ANTI-SCL-70 (topoisomerase)
Scleroderma Treatment
Sclerodactyly=Penacillamine
Esophageal=PPI
Raynauds/Calcinosis=CCB
Sjogrens Presentation, Dx, Tx
Dry eyes, Dry Mouth, Parotid Swelling Dx: ANA, RF serology RO and La Schirmer test Tx: Artifical tears, saliva
Idiopathic Inflammatory Myopathy Presentation, Dx, Tx
Proximal muscle weakness, Painless, Subacute, malignancy heliotrope rash Grottens papules-symmetrical Shawl Sign Dx: Increased CK EMG Anti Mu, Jo Tx: Steroids