Rheumatology Flashcards
1
Q
What are the diagnostic criteria for juvenile idiopathic arthritis?
A
- Symptoms must be present prior to the age of 16
- Symptoms must be present for at least six weeks
- Arthritis more common in large joints
- Positive rheumatoid factor indicates worse prognosis
- Negative RF does not rule out RA
2
Q
What are the features of oligoarticular JIA?
A
- Affecting four or fewer joints
- Usually + ANA
- RF usually negative
- More common in younger girls
- Associated with chronic uveitis
3
Q
What are the features of polyarticular JIA?
A
- Affecting five or more joints
- More common in young girls
4
Q
What are the features of systemic JIA?
A
- Still’s Disease
- Equally common in boys and girls
- Episodic, salmon colored evanescent rash
- Extremely high leukocytosis
- Spiking fevers
- Lymphadenopathy
- Hepato-splenomegaly
- Pleurisy
- Pericarditis
- Korbner phenomenon: when your skin lesions appearing along a site of injury, rubbing, scratching
- Negative serum markers
5
Q
What are the serum markers for SLE?
A
- ANA antibodies: most sensitive but not very specific
- anti-DNA antibodies: next most sensitive
- anti-Smith antibodies: most specific and diagnostic
- RPR
6
Q
How do you diagnose neonatal lupus?
A
Send anti-Ro or anti-La antibodies
aka, anti-SS-A or SS-B
7
Q
What are the features of juvenile ankylosing spondylitis?
A
- Fusion of the spine (“bamboo spine”)
- Inflammation of the hips
- Males are more often affected
- Inflammation of SI joint
- Pain is worse with rest
- May also have iritis and uveitis
8
Q
What are the features of dermatomyositis?
A
- Heliotropic, violaceous rash in malar area
- Gottron’s papules (erythematous, shiny, pruritic papules over the metacarpals)
- Proximal weakness
- Telangiectasias near the nail folds
- Diagnosed with muscle biopsy
- High CK level
