Rheumatology Flashcards
Antiphospholipid Sx: bloods
Prolonged APTT and low platelets
PO bisphosphonates prior to starting
Correct hypocalcaemia & vitamin d
Osteoporosis
Ca: normal
PO4: normal
ALP: normal
PTH: normal
Osteomalacia
Ca: decreased
PO4: decreased
ALP: Increased
PTH: Increased
CKD
Ca: decreased
PO4: increased
ALP: increased
PTH: increased
Paget’s
Ca: normal
PO4: normal
ALP: increased
PTH: normal
Osteosarcoma
Most frequently in long bones prior to growth plate fusion
Lupus: antibodies
ANA +ve
Anti-histone
Meralgia paraesthetica
Compression of lateral cutaneous nerve
Hypersensitivity reactions: I
Anaphylaxis
Hypersensitivity reactions: II
Cell bound
Autoimmune
Hypersensitivity reactions: III
Immune complex
SLE, post strep GN
Hypersensitivity reactions: IV
delayed hypersensitivity
Osteomalacia: features
Bone pain
Bone tenderness
Waddling gait
OP: >75 years
Fragility # and over 75 start bisphosphonates without DEXA
DEXA: >-2.5
Confirmed OP
Psoriatic arthropathy: cf
Symmetrical polyarthritis
Asymmetrical oligoarthritic
DIP disease
MTX: SE
Myelosuppression
Liver cirrhosis
Pneumonitis
Sulfasalazine: SE
Rashes
Oligospermia
Heinz body anaemia
ILD
RA: Poor prognosis features
Rh factor +ve
Anti-CCP ABs
Poor functional status
Early erosions
Extra articular features
HLA DR4
Insidious onset
RA: X ray changes
Loss of joint space
Juxta-articular OP
Soft tissue swelling
Periarticular erosions
Subluxation
Systemic sclerosis: Antibodies
ANA +ve in 90%
RF +ve in 30%
Bloods before azathioprine
TPMT
Sjogren’s antibodies
Anti-Ro
