Rheumatoid factor AND ASO Flashcards
an auto immune and inflammatory disease
→ Immune system attacks healthy cells of the body by mistake, causing
inflammation (painful swelling)
a. Psoriatic arthritis
b. Viral polyarthritis
c. Rheumatoid arthritis
c. Rheumatoid arthritis
Cause of Rheumatoid arthritis
a. age
b. sex
c.genetics
d.unknown
e. none of the above
d.unknown
They have postulated due to arrangement and somatic hypermutations
of germline genes
Rheumatoid factor
common isotype in rheumatoid factor
IgM RF
a score of ? is definite RA diagnosis
6
Cells involved in RF production
a. CD4+ T cells, activated lymphocytes, plasma cells,
macrophages
b. activated lymphocytes and plasma cells
c. plasma cells and
macrophages
d. CD4+ T cells and macrophages
e. none of the above
CD4+ T cells, activated lymphocytes, plasma cells,
macrophages
ACR
American college of rheumatology
percentage of RA patients are positive to RF.
70 to 90%
Positive RF does not indicate positive RA right away since it is also
seen in 5% healthy persons, 10-25% over age 65. TRUE OR FALSE
TRUE
it is a latex agglutination test for anti streptolysin O
anti streptolysin O latex test kit
AOS increase within how many weeks after infection?
1 to 2 weeeks
AOS titers is not helpful for individuals with skin infections. TRUE OR FALSE
true
Detect antibodies to the streptolysin O enzyme produced by group A
streptococcus
anti streptolysin O
→ It detects mostly IgM-RF isotypes
manual Passive Agglutination test
used as a screening test ASO
Qualitative test
