Rheumatoid Arthritis Drugs

Question 1

How do NSAIDs work?

Answer 1

Question 2

What is a bridging therapy for DMARDs

Answer 2

And Glucocorticoids

Question 3

What are the different COX enzymes? Which are you normally trying to inhibit?

Answer 3

Question 5

What are glucocorticoids, how do they work on the body?

Answer 5

Question 6

What is the main glucocorticoid that we need to know for Rheumatoid arthritis?

Answer 6

Prednisone

Question 7

What are the two main mechanisms of DMARDs?

What is the main aim of using a DMARD?

What do DMARDs NOT do?

Answer 7

Aim: therapeutic remission or stop the progression of the disease.

Drawback: They are immunosuppressing so need to look for neutropenia.

They are not anti-inflammatory or analgesic.

Question 8

First line DMARD used?

How does it work?

Side effects?

Answer 8

Question 9

What are the 2nd line DMARDS?

Answer 9

Question 10

What are the TNF-alpha inhibitors? How do they work?

Answer 10

TNF binds to some receptors: TNF alpha is important in immune response.

Drug: receptor for TNFalpha without the transmembrane domain which binds up all the TNFa therefore cannot bind to the endogenous receptor (competitive inhibition).

You can also do this by creating an antibody which binds to the TNF binding site for the receptor.

Question 11

Answer 11