Gut motility pharmacology Flashcards
Acetylcholine (ACh) and Serotonin (5HT) are produced by what, act through what and have what affect?
Histamine and Substance P are produced by what, act through what and have what affect?
Dopamine is produced by what, act through what and have what affect?
What is nausea?
What is emesis?
Explain the vestibular system?
What is it sensitive to?
Explain the chemoreceptor trigger zone?
What is it responsible to and for?
Explain the vomiting centre?
3 major drug classes to help with treatment of GIT disorders
Metoclopramide indication, mechanism of action, side effects?
Cyclizine indication, mechanism of action and side effects for GIT treatment?
Promethazine indications, MOA and side effects?
Scopolamine MOA, indications and side effects?
Ondansetron MOA, indication and side effects?
Cholinergic effects are…
Cannabinoids MOA, indications and side effects?
What causes constipation?
What causes diarrhoea?
Explain the control of motility with ACh, Seritonin and Dopamine?
How is this controlled?
3 types of neurotransmitters.
Ach works on the M receptors on the longitudinal muscles. Increasing peristalsis and helping things push along. When acting reduction in segmentation. Segmentation is controlled more by the food that is passed through which is stimulated by fatty acids.
Serotonin: acts on the ECL cells through 5ht receptors which causes increase in Ach production, therefore, increase in peristalsis and motility.
Dopamine does the opposite: made by the epithelial cells and acts on D receptors and decreases Ach production.
How do bulk laxitives and surfactants work?
How do osmotic laxitives work?
Indications and side effects?
Prokinetics/stimulants indications, side effects MOA.
What happens with laxative abuse?
How does hyocine work? Indications and side effects?
Lopramide MOA, indications and side effects?
