Gut acid pharmacology

Question 1

Answer 1

Question 2

What does gastrin do to acid secretions? Mechanism?

What negative feedback does this have?

Answer 2

Question 3

What can shut off acid secretion?

What else does this molecule affect?

Answer 3

Prostaglandin E2.

Activated neck and surface cells to secrete mucous and HCO3- (ACh also activates this pathway).

Question 4

What is GORD?

What can it lead to?

Answer 4

Question 5

Why does H. pylori cause ulcers to form?

Answer 5

Question 6

What treatment is used for mild GORD?
Give an example?

Side effects?

Answer 6

Mylanta: cautious with heart failure.

Question 7

Advanced treatments for GORD (3 drug types).

Give example, side effects and MOA.

Answer 7

Question 8

How does omeprazole work? Side effects and indications?

Answer 8

Long term use can cause increased risk of bone fractures, malabsorption of nutrients etc, increased risk of C. diff infections.

Question 9

Ranitidine MOA, indications side effects?

Answer 9

Histamine receptor antagonist (prevention action from ECL cells).

Question 10

Prophylaxis treatment for peptic ulcers?

Answer 10

Question 11

Misoprostol indication, side effects and MOA?

Answer 11

Question 12

Eradication therapy for H. pylori?

Answer 12

Tripple therapy with omeprazole, clarithromycin/amoxycillin and metronidazole (omeprazole plus 2 antibiotics).

Question 13

Answer 13