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Pharm 1 Final Exam > Rheumatoid Arthritis COPY > Flashcards

Rheumatoid Arthritis COPY Flashcards

1
Q

What type of disease is RA?

A

systemic inflammatory disease

autoimmune disease

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2
Q

What are the symptoms of RA

A 
joint inflammation (BILATERALLY)
whole person is sick
fatigue
general malaise
low grade temperature
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3
Q

Pharmacological goals of tx of RA

A

Provide symptomatic relief

Delay progression of disorder

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4
Q

some of drugs used for tx of RA are also used for

A

antirejection drugs in organ transplant

and management in IBD

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5
Q

provides rapid, symptomatic relief of inflammation and pain in RA

A

NSAIDS

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6
Q

steriods

A

antiinflammatories

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7
Q

provide symptomatic relief of inflammation and pain

A

glucocorticoids

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8
Q

What are the routes glucocorticoids are administered?

A

IV, oral or intraarticular (injected into inflammed joint)

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9
Q

Side effects of steriods

A

immunosupression

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10
Q

Potassium rich diets include

A

bananas potatoes and apricot

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11
Q

DMARDS stands for

A

disease modifying anti-Rheumatic drugs

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12
Q

Function of DMARDS

A

slow joint degeneration

slow progression of disease

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13
Q

Downfalls of DMARDS

A

take a while to work

very toxic

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14
Q

Which is cheaper DMARS biologic/nonbiologic

A

nonbiologic

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15
Q

How do antimalarial drugs work against RA? Example of antimalarial drgu

A

theyre antiinflammatories

Hydroxycholorquine/Plaquenil

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16
Q

Hydroxycholorquine/Plaquenil SE***

A

retinal damage/blindness***

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17
Q

DMARDS I- Nonbiologic Include

A 
Rheumatrex
Arva
Antiinflammatories: - sulfasalazine
Antimalarial drugs- hydroxychloroquine/plaquinil
tetracyclines
18
Q

Drug used for IBS, GI discomfort, liver damage, bone marrow supression

Q: which class

A

Sulfasalazine

non-major biologic DMARDS-1

19
Q

What is the drug of choice for RA?

A

rhumatrex

20
Q

how often is rhumatrex given?

A

once a week

21
Q

rhumatrex other uses

A

cancer
psoriasis
other immune diseases

22
Q

which drug is a folic acid analog

A

rhumatrex

23
Q

DMARDS II

A

Major biologic response modifiers

immune modulators

24
Q

etanercept/ENBREL function
Q2: what category does it fall under
Q3: route

A

immunosupressant
DMARDS II
injectable

25
Q

etanercept/ENBREL function SE**

A 
**local reaction injection issues
risk of infection
skin reax
immunosupressant
heart failure
blood dyscrasias
increases risk of herpes zoster
26
Q

etanercept/ENBREL class

A

DMARDS II major biologic

27
Q

DMARDS III

A

minor nonbiologic and biologic

Gold salts
penicillamine
Cytotoxic drugs- Imuran
Antirejection drugs

28
Q

Gold salts comes with a risk of

A 
toxicity
rashes
stomatitis
renal toxicity
blood dyscrasias
inflamed liver- hepatitis
GI disturbances
(When you give gold you are killing cells)
29
Q

Penicillamine SE

A

can cause bone marrow supression

toxicity

30
Q

Penicillamine is what type of drug

A

DMARDS III

31
Q

penicillamine

Class

A

NOT an antibiotic

DMARDS III

32
Q

When you give elemenets that kill cells it is called

A

elemental pharmacology

33
Q

Anti rejection drugs SE

A

come with a risk of infection
hepatotoxicity
nephrotoxicity
hirsuitism

34
Q

Antirejection drugs are what class

A

DMARDS III

35
Q

people who cant tolerate rheumatrex/dont want to take injectable would take

A

Xeljanx

36
Q

Xeljanx can be taken with biologic/nonbiologic?

Q2: what other medications

A

Nonbiological DMARDS

Rheumatrex and Methotrexate.

37
Q

Xeljanz function

A

decreases immune response to supress inflammation

38
Q

Xeljanz cannot be taken with

A

biologic DMARDS

immunosupressants (cyclosporine and azathioprine)

39
Q

cytotoxic drug used as chemo

A

penicilamine

DMARDS III

40
Q

people who cannot tolerate rhumatrex or methotrexate can use

A

Xeljanz

Pharm 1 Final Exam (16 decks)

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