Rheumatoid Arthritis COPY

Question 1

What type of disease is RA?

Answer 1

systemic inflammatory disease

autoimmune disease

Question 2

What are the symptoms of RA

Answer 2

joint inflammation (BILATERALLY)
whole person is sick
fatigue
general malaise
low grade temperature

Question 3

Pharmacological goals of tx of RA

Answer 3

Provide symptomatic relief

Delay progression of disorder

Question 4

some of drugs used for tx of RA are also used for

Answer 4

antirejection drugs in organ transplant

and management in IBD

Question 5

provides rapid, symptomatic relief of inflammation and pain in RA

Answer 5

NSAIDS

Question 6

steriods

Answer 6

antiinflammatories

Question 7

provide symptomatic relief of inflammation and pain

Answer 7

glucocorticoids

Question 8

What are the routes glucocorticoids are administered?

Answer 8

IV, oral or intraarticular (injected into inflammed joint)

Question 9

Side effects of steriods

Answer 9

immunosupression

Question 10

Potassium rich diets include

Answer 10

bananas potatoes and apricot

Question 11

DMARDS stands for

Answer 11

disease modifying anti-Rheumatic drugs

Question 12

Function of DMARDS

Answer 12

slow joint degeneration

slow progression of disease

Question 13

Downfalls of DMARDS

Answer 13

take a while to work

very toxic

Question 14

Which is cheaper DMARS biologic/nonbiologic

Answer 14

nonbiologic

Question 15

How do antimalarial drugs work against RA? Example of antimalarial drgu

Answer 15

theyre antiinflammatories

Hydroxycholorquine/Plaquenil

Question 16

Hydroxycholorquine/Plaquenil SE***

Answer 16

retinal damage/blindness***

Question 17

DMARDS I- Nonbiologic Include

Answer 17

Rheumatrex
Arva
Antiinflammatories: - sulfasalazine
Antimalarial drugs- hydroxychloroquine/plaquinil
tetracyclines

Question 18

Drug used for IBS, GI discomfort, liver damage, bone marrow supression

Q: which class

Answer 18

Sulfasalazine

non-major biologic DMARDS-1

Question 19

What is the drug of choice for RA?

Answer 19

rhumatrex

Question 20

how often is rhumatrex given?

Answer 20

once a week

Question 21

rhumatrex other uses

Answer 21

cancer
psoriasis
other immune diseases

Question 22

which drug is a folic acid analog

Answer 22

rhumatrex

Question 23

DMARDS II

Answer 23

Major biologic response modifiers

immune modulators

Question 24

etanercept/ENBREL function
Q2: what category does it fall under
Q3: route

Answer 24

immunosupressant
DMARDS II
injectable

Question 25

etanercept/ENBREL function SE**

Answer 25

``` **local reaction injection issues risk of infection skin reax immunosupressant heart failure blood dyscrasias increases risk of herpes zoster ```

Question 26

etanercept/ENBREL class

Answer 26

DMARDS II major biologic

Question 27

DMARDS III

Answer 27

minor nonbiologic and biologic Gold salts penicillamine Cytotoxic drugs- Imuran Antirejection drugs

Question 28

Gold salts comes with a risk of

Answer 28

``` toxicity rashes stomatitis renal toxicity blood dyscrasias inflamed liver- hepatitis GI disturbances (When you give gold you are killing cells) ```

Question 29

Penicillamine SE

Answer 29

can cause bone marrow supression | toxicity

Question 30

Penicillamine is what type of drug

Answer 30

DMARDS III

Question 31

penicillamine | Class

Answer 31

NOT an antibiotic | DMARDS III

Question 32

When you give elemenets that kill cells it is called

Answer 32

elemental pharmacology

Question 33

Anti rejection drugs SE

Answer 33

come with a risk of infection hepatotoxicity nephrotoxicity hirsuitism

Question 34

Antirejection drugs are what class

Answer 34

DMARDS III

Question 35

people who cant tolerate rheumatrex/dont want to take injectable would take

Answer 35

Xeljanx

Question 36

Xeljanx can be taken with biologic/nonbiologic? | Q2: what other medications

Answer 36

Nonbiological DMARDS | Rheumatrex and Methotrexate.

Question 37

Xeljanz function

Answer 37

decreases immune response to supress inflammation

Question 38

Xeljanz cannot be taken with

Answer 38

biologic DMARDS | immunosupressants (cyclosporine and azathioprine)

Question 39

cytotoxic drug used as chemo

Answer 39

penicilamine | DMARDS III

Question 40

people who cannot tolerate rhumatrex or methotrexate can use

Answer 40

Xeljanz