Rheumatoid Arthritis

Question 1

Pannus

Answer 1

Inflamed, proliferating tissue

Question 2

CD28 binds to what to become activated?

Answer 2

CD80/86

Question 3

An ACR/EULAR score greater than ____ is a diagnosis of RA.

Answer 3

6

Question 4

Non-Pharm Tx of RA

Answer 4

Smoking cessation
Rest
Physical therapy
Weight loss
Surgery

Question 5

What HLA antigens put you at a higher risk of developing RA?

Answer 5

HLA-DRB1

HLA-DRB4

Question 6

What are some comorbidities that put you at a higher risk for developing RA?

Answer 6

T1 and T2DM
Inflammatory lung disease
Dyslipidemia

Question 7

What are some protective environmental factors for RA?

Answer 7

Fish oil, olive oil
Alcohol consumption
Schizophrenia

Question 8

Describe Synovitis.

Answer 8

Infiltration of inflammatory cells into the synovial tissue

Pannus present

Question 9

What CD factors must bind for T cells to be activated?

Answer 9

CD80/86 and CD28

Question 10

What are some possible drug targets for RA?

Answer 10

B-cells
TNF-alpha
IL-1 and IL-6

Question 11

Joints involved in RA

Answer 11

Metacarpophalangeal, proximal interphalangeal, second through fifth metatarsophalangeal, thumb interphalangeal, wrist

Question 12

Describe the difference between RA and osteoarthritis.

Answer 12

RA is morning stiffness longer than 30 minutes
RA doesn’t increase with age
RA shows an increase in ESR
RA is symmetrical joint inflammation

Question 13

What are comorbities that you need to manage in RA?

Answer 13

Infection
Osteoporosis
CVD