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PPS 946 > BPH > Flashcards

BPH Flashcards

1
Q

MOA Alpha Blockers

A

Reduce smooth muscle tone

Works on Receptor Alpha-1A

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2
Q

What time of day do you administer the first dose of an alpha-blocker?

A

At bedtime

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3
Q

What do you do to avoid postural hypotension and syncope when starting alpha-blockers?

A

Alpha-Blockers must be titrated in a step-wise fashion.

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4
Q

MOA of Tamsulosin

A

Selective alpha-1A receptor

Don’t have to do stepwise titrations.

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5
Q

Side effect of tamsulosin

A

Interrupts ejaculations

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6
Q

MOA of Alfuzosin

A

Uroselective alpha adrenergic selective

No ejaculation disruption

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7
Q

Silodosin

A

Alpha-1A receptor specific

Increase in ejaculatory disturbances

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8
Q

5-alpha Reductase Enzyme Inhibitors

A

Blocks DHT producion

Good for patients with large prostate.

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9
Q

Finasteride

A

Blocks conversion of testosterone to DHT by inhibiting Type 2 5-alpha reductase

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10
Q

What does long term administration of Finasteride cause?

A

Prostate shrinkage

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11
Q

Dutasteride

A

Inhibits peripheral and prostate specific enzymes

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12
Q

VA Trial 359

A

Results:
Terazosin is superior to finasteride
Finasteride is no more effective than the placebo
Combination therapy was not synergistic

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13
Q

MTOPS

A

Said Alpha-blocker and 5AREI combo slows progression the best.

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14
Q

CombAT Trial

A

Said that men with enlarged prostate benefit best when using 5AREI with or without an alpha-blocker

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15
Q

Flutamide

A

Prevents DHT binding to receptor

Saved for nonsurgical candidates, finasteride failures, and patients that cannot use alpha-blockers

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16
Q

Acute Bacterial Prostatitis

A

Sudden onset of fever, tenderness, and urinary/constitutional sypmtoms

17
Q

Chronic Bacterial Prostatitis

A

Urinating difficulty, low back pain

Recurring infections with same organism

18
Q

Treatment for Acute Bacterial Prostatitis

A

Bactrim, fluoroquinolones, cephalosporins for 4 weeks to reduce development of chronic prostatitis

19
Q

Treatment for Chronic Bacterial Prostatitis

A

Trimethoprim and fluoroquinolones

PPS 946 (22 decks)

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