Rheumatoid arthritis Flashcards
What are the general features of RA?
Inflammatory + Symmetrical + Polyarthritis
* Destruction of joints due to erosion of bone and cartilage
* Stretching of tendons and ligaments
Progresses from periphery to more proximal joints and results in locomotor disability
Joint distribution
* Affects hands (PIP/ MCP/ IP of thumbs), wrists, feet (MTP) in the early stages
* Involve other synovial joints including shoulder, elbow, knees and ankles
What is the pathogenesis of RA?
What are the SS of RA?
What are the specific joints involvement in hand RA?
How are the wrist, elbow, shoulder
Lower extremities: feet, knees
Cervical spine
Others involved in RA
What are the systemic and non articular manifestation of RA?
What is the ddx for RA?
How to clinically assess RA?
What is the diagnostic criteria for RA?
Three ‘A’s and two ‘6’s
1. Arthritis
2. Antibodies (anti-CCP, RF)
3. Acute phase reactants (ESR, CRP)
- 6 weeks duation
<6 weeks duration: 0
>6 weeks duration: 1 - > 6/10 points = Definite RA
What are the Ix done for RA?
What is the medical treatment for RA?
Mnemonic: ELISA Please Give Her Methotrexate
E-Etanercept
L-Leflunomide
I-Infliximib
S-Sulfasalazine
A-Anakinra
P-Penicillamine
G-Glucocorticoid + Gold salts
H-Hydroxychloroquine
M-Methotrexate
What is the prognostic factors for RA?
What is the disease activity assessment of RA?
What is the response criteria for RA?
What are the complications of long-standing rheumatoid arthritis?
Descirbe the types of drugs used to treat RA and their complications?
