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PEDS > Rheumatic Diseases > Flashcards

Rheumatic Diseases Flashcards

1
Q

What type of inflammation is seen in juvenile idiopathic arthritis?

Inflammation of synovium

A

Non-suppurative

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2
Q

S/Sx of Juvenile idiopathic Arthritis.

A
  • Fever
  • Rheumatic rash
  • Hepatosplenomegaly
  • Lymphadenopathy
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3
Q

What joints are usually spared in polyarticular juvenile idiopathic arthritis?

A

Lumbasacral

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4
Q

Which gender is more affected by polyarticular juvenile idiopathic arthritis?

A

Female

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5
Q

At what age does polyarticular juvenile idiopathic arthritis typically arise?

A

> 8 yo

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6
Q

What joints are typically affected by polyarticular juvenile idiopathic arthritis?

A

Larger joints

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7
Q

Type II polyarticular juvenile idiopathic arthritis is associated with what HLA marker?

A

HLA-DR4

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8
Q

What laboratory data leads to the Dx of pauciarticular JIA?

A
  • Anemia
  • Leukamoid reactions
  • Increased platelets
  • cloudy synovial fluid w/ increased protein
  • Soft tissue swelling (on XR)
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9
Q

SE of ASA Tx in Pauciarticular JIA.

A
  • Hyperventilation
  • Drowsiness
  • Tinnitus
  • Reyes syndrome
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10
Q

What type of onset of JIA displays large joint involvement symmetrically?

A

Pauciarticular JIA

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11
Q

What is the most common type of Pauciarticular JIA?

A

Type I

HLA-DR5, HLA-DR6, HLA-DR8, ANA

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12
Q

50% of children with pauciarticular JIA will display what type of involvement?

A

Eye; iridocyclitis (anterior chamber of eye)

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13
Q

Unlike polyarticular JIA, pauciarticular JIA displays involvement in which joints?

A

Lumbosacral

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14
Q

What are the HLA and ANA factors of Type I Pauciarticular JIA?

A
  • HLA-DR5
  • HLA-DR6
  • HLA-DR8
  • Increased ANA
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15
Q

What are the HLA & ANA factors of Type II Pauciarticular JIA?

A
  • HLA-B27
  • No increase in ANA
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16
Q

Reyes syndrome can be caused by the administration of what medication to a pediatric patient?

A

Aspirin

17
Q

The rash will be from the waist down in which disease?

A

Henoch-Schonlein Purpura

18
Q

In Henoch-Schonlein Purpura, a patient will display what type of purpura?

A
  • Nonthrombocytopenic purpura
  • Rash from waist down
19
Q

Why does muscle inflammation occur in calcinosis?

A

Ca2+ deposits within muscle tissue

20
Q

What type of patches are noted with calcinosis (dermatomyositis)?

A

Guttron patches (red, scaly patches on elbows, knee, and knuckles)

21
Q

The rash in dermatomyositis involves what folds?

A

Nasolabial folds

22
Q

What clinical feature is noted symmetrically in calcinosis (dermatomyositis)?

A

Symmetric weakness of proximal muscles (e.g., hips & legs)

23
Q

What factor is positive in most pediatric patients with SLE?

A

ANA

24
Q

What are the clinical features of SLE in pediatric patients?

A
  • Ulcers in mouth
  • Malar rash (nasolabial folds are spared)
  • Scarring alopecia
  • Cutaneous vasculitis
25
Q

What is the Triphasic course of Kawasaki disease?

A
  • Acute: fever, nonpurulent conjunctivitis, rash, orpharyngeal edema
  • Subacute: peeling of hands & feet
  • Convalescent: cracked lips & strawberry tongue
26
Q

A fever of >5 days may indicate what disease?

A

Kawasaki disease

27
Q

What are the (5) diagnostic features of Kawasaki Syndrome?

4/5 must be present for Dx

A
  • Bilateral conjunctivitis
  • Strawberry tongue
  • Changes in peripheral extremities
  • Rash (Non-vesicular)
  • Cervical lymphadenopathy

PEDS (7 decks)

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