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Pharmacology drugs of the pathologies > Rheum > Flashcards

Rheum Flashcards

1
Q

Bisphosphates (osteoporosis example)?

A

Anti-resorptive decreasing OC activity and bone turnover

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2
Q

How do bisphosphates work?

A

Inhibit the enzyme in the cholesterol synthesis pathway

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3
Q

Anabolic action in osteoporosis?

A

Increase osteoblastic activity and bone formation

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4
Q

Denosumab action in osteoporosis?

A

Decrease reabsorption

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5
Q

Teriparatide action in osteoporosis?

A

PTH analogue: reduce fracture risk and increase bone density

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6
Q

Ankylosing spondylitis treatments 1st, 2nd, 3rd line?

A

1st line: exercise and physio
2nd line: NSAIDs
3rd line: anti-TNF alpha

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7
Q

1 in 4 chance someone with the HLA-B27 gene will develop what?

A

Spondyloarthritis or eye disease

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8
Q

Amitriptyline is a…?

A

Anti-depressant

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9
Q

Pain management treatments?

A

Analgesia, acupuncture, CBT, encourage aerobic exercise

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10
Q

Which cytokines (x3) will mediate osteoarthritis?

A

IL1, TNF-alpha, NO

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11
Q

Why is allopurinol prescribed in gout patient prevention?

A

Lowers the blood uric acid levels

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12
Q

Allopurinol mechanism of action?

A

Xanthine oxidase inhibitor

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13
Q

Treatment for acute gout flare-up?

A

Joint aspiration and NSAIDS or colchicine if CI

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14
Q

Triple treatment for staphyloccous aureus?

A

Flucloxacillin, erythromycin, doxylteracycline

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15
Q

Typical drug treatment for RA?

A

DMARDs: methotrexate, sulphasalazine, hydroxychloroquine, leflunomide

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16
Q

What is the steroid used for acute exacerbations of RA?

A

IM methylprednisolone

17
Q

LESS on X-ray for RA?

A

Loss of joint space
Erosions
Soft tissue swelling
Soft bones

18
Q

SLE severe flare-ups treatment?

A

High dose prednisolone, IV cyclophosphamide

19
Q

SLE management list of drugs:

A

NSAIDs and hydroxychloroquine
Topical steroids
Biologics - Rituximab in B cell depletion
Anti-malarial

20
Q

What should be given to a antiphospholipid syndrome patient who is trying to conceive?

A

LMW Heparin or warfarin to act as an anticoagulant

21
Q

Treatment for SICCA complex Sjogren’s syndrome patient?

A

Artificial tears, frequent drinks, non-sugar pastilles

NSAIDs for arthralgia

22
Q

Treatment for Raynaud’s syndrome?

A

Calcium channel blockers

23
Q

Systemic sclerosis treatment?

A

Immunosuppression and anti-hypertensives (ACEi) and gentle skin stretching

24
Q

Polymyositis skin problems treatment?

A

Prednisolone and tacrolimus

25
Q

Treatment for vasculitis?

A

Prednisolone

Or other high dose steroids including cyclophosphamide

Pharmacology drugs of the pathologies (4 decks)

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