Rh Blood Group System Flashcards

1
Q

Rh antibodies were demonstrated by who?

A

Landsteiner & Weiner

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2
Q

RhD and RHCE genes are linked to what chromosome?

A

Chromosome 1

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3
Q

RhAG is found at chromosome ____

A

Chromosome 6

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4
Q

The Rh glycoprotein is made up of _____ amino acids that traverses the plasma membrane ___ times

A

416

12

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5
Q

Rh null individuals suffers a particular RBC morphology abnormality called ____

A

Stomatocytosis

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6
Q

What number is responsble for antigen C and c?

A

103

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7
Q

d antigen denotes what?

A

Absence of D antigen

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8
Q

What is difference between Rh null and Rh-?

A

Rh null = all genes are absent
Rh- = only D is absent

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9
Q

Convert from Fisher-Race to Weiner:

DcE

A

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10
Q

Convert from Fisher-Race to Weiner:

DCE

A

Rz

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11
Q

Convert from Fisher-Race to Weiner:

ce

A

r

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12
Q

Convert from Weiner to Fisher-Race:

ry

A

CE

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13
Q

Convert from Weiner to Fisher-Race:

A

cE

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14
Q

Convert from Fisher-Race to Rosenfield:

DCe/DcE

A

Rh: 1, 2, 3, 4, 5

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15
Q

Convert from Fisher-Race to Rosenfield:

DCe/dce

A

Rh: 1, 2, -3, 4, 5

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16
Q

Why are Rh antigens much more fatal if invovled in Hemolytic Disease of
the Fetus and Newborn?

A

Mainly because they are well-developed early in the fetal life

17
Q

Why is the first pregnancy safe regarding HDFN?

A

It is the first time that the mother is exposed to the antigen

18
Q

How immunogenic is the Rh antigen?

A

It only requires 0.1 mL of Rh positive RBC to stimulate antibody production

19
Q

Rh antibody starts as what type of immunoglobulin?

A

IgM

20
Q

What is used for detecting the D antigen?

A

Anti-D

21
Q

Rh antigens are located in the _____

A

Rh glycoprotein

22
Q

Rh glycoprotein is composed of how many amino acids?

A

416

23
Q

When an individual has Weak D, is there a of D antigens?

A

Yes, but it is decreased

24
Q

Weak D was formerly regarded as ____

A

Du phenotype

25
Q

What are the 3 mechanisms of weak D?

A

Genetic Weak D
C trans
Partial D (Mosaic D)

26
Q

How are the 3 mdchanisms of Weak D differentiated?

A

Genetic Weak D - Weak D Test
C trans - Monoclonal reagents
Partial D - Monoclonal and Weak D Test

27
Q

Genetic Weak D is most common among ____.

A

Blacks

28
Q

Asians are mostly Rh ___.

A

Positive (+)

29
Q

What test is used to check for genetic Weak D?

A

Indirect Antiglobulin Test (IAT)

30
Q

Indirect Antiglobulin Test is also known as _____.

A

Indirect Coombs Test

31
Q

What happens to the RhD and RhCe in Trans position of Weak D?

A

Opposite to each other

32
Q

Partial D phenotypes should be suspected if:

A

A D+ individual produces an Anti-D but it doesn’t react with their own RBCs

33
Q

When a Partial D patient is in need of blood transfusion, what blood is going to be used? How about if they are the one donating?

A

D negative as recipient

D positive as donor

34
Q

IAT is used to detect _____

A

In vitro sensitization

35
Q

DAT is used to detect ____

A

In vivo sensitization

36
Q

Coombs check cells are comprised of:

A

Group O blood
RBCs sensitized with IgG