Rh Blood Group System Flashcards
Rh antibodies were demonstrated by who?
Landsteiner & Weiner
RhD and RHCE genes are linked to what chromosome?
Chromosome 1
RhAG is found at chromosome ____
Chromosome 6
The Rh glycoprotein is made up of _____ amino acids that traverses the plasma membrane ___ times
416
12
Rh null individuals suffers a particular RBC morphology abnormality called ____
Stomatocytosis
What number is responsble for antigen C and c?
103
d antigen denotes what?
Absence of D antigen
What is difference between Rh null and Rh-?
Rh null = all genes are absent
Rh- = only D is absent
Convert from Fisher-Race to Weiner:
DcE
R²
Convert from Fisher-Race to Weiner:
DCE
Rz
Convert from Fisher-Race to Weiner:
ce
r
Convert from Weiner to Fisher-Race:
ry
CE
Convert from Weiner to Fisher-Race:
r²
cE
Convert from Fisher-Race to Rosenfield:
DCe/DcE
Rh: 1, 2, 3, 4, 5
Convert from Fisher-Race to Rosenfield:
DCe/dce
Rh: 1, 2, -3, 4, 5
Why are Rh antigens much more fatal if invovled in Hemolytic Disease of
the Fetus and Newborn?
Mainly because they are well-developed early in the fetal life
Why is the first pregnancy safe regarding HDFN?
It is the first time that the mother is exposed to the antigen
How immunogenic is the Rh antigen?
It only requires 0.1 mL of Rh positive RBC to stimulate antibody production
Rh antibody starts as what type of immunoglobulin?
IgM
What is used for detecting the D antigen?
Anti-D
Rh antigens are located in the _____
Rh glycoprotein
Rh glycoprotein is composed of how many amino acids?
416
When an individual has Weak D, is there a of D antigens?
Yes, but it is decreased
Weak D was formerly regarded as ____
Du phenotype
What are the 3 mechanisms of weak D?
Genetic Weak D
C trans
Partial D (Mosaic D)
How are the 3 mdchanisms of Weak D differentiated?
Genetic Weak D - Weak D Test
C trans - Monoclonal reagents
Partial D - Monoclonal and Weak D Test
Genetic Weak D is most common among ____.
Blacks
Asians are mostly Rh ___.
Positive (+)
What test is used to check for genetic Weak D?
Indirect Antiglobulin Test (IAT)
Indirect Antiglobulin Test is also known as _____.
Indirect Coombs Test
What happens to the RhD and RhCe in Trans position of Weak D?
Opposite to each other
Partial D phenotypes should be suspected if:
A D+ individual produces an Anti-D but it doesn’t react with their own RBCs
When a Partial D patient is in need of blood transfusion, what blood is going to be used? How about if they are the one donating?
D negative as recipient
D positive as donor
IAT is used to detect _____
In vitro sensitization
DAT is used to detect ____
In vivo sensitization
Coombs check cells are comprised of:
Group O blood
RBCs sensitized with IgG
