Other Common Blood Groups Flashcards
ISBT number of Le
007
How is the Lewis system unique?
It is intrinsic in the glycosphingolipids
Chromosome and location of Lewis group
Chromosome 19
19p13.3
Lewis group is resistant to what enzymes?
Ficin
Papain
DTT
Glycin-acid EDTA
Lewis phenotype that is found at 10-40% of the Asian population
Le (a+b+)
Le phenotype that is an ADH secretor
Le (a-b+)
Le (a-b-) is common among _____
Black people
What is the enzyme that the Lewis system produces?
a1,4-L-fucosyltransferase
The most common antibody encountered from the Lewis system
Anti-Leª
Lewis antibodies are made by individuals with what phenotype?
Le(a-b-)
Glycolipids are detectable after ___ days since birth
10
Le non-secretors presents what phenotype at birth?
Le(a-b-)
Le^ab is formerly known as ___
Le^x
What is the precursor of the p1 antigen?
Type 2 oligosaccharide chain
P1PK blood group can be found where?
Platelets, epithelial cells, fibroblasts
What is the only blood group system that ia not manufactured by the RBCs
Lewis system
ISBT number of P1PK
003
ISBT number of Globoside system
028
ISBT number of globoside collections (Luke-LKE)
209
Phenotypes expressed by an individual with Globoside BGS
P, PX2
Where are the P1Pk gene and A4GALT gene located at?
Chromosome 22, position 22q13.5
Where is the location of Globoside, B3GALNT1 gene?
Chromosome 3, position 3q25
P1Pk antibody produced by individuals with null phenotypes
Anti-P1Pk
Anti-P1Pk antibody may cause ____
HTR and HDFN
A naturally occuring IgM present on Pk individuals
Alloanti-P
Alloanti-P reacts at what temperature?
37°C
A cold reacting IgG antibody that is associated with paroxysmal cold hemoglobinuria
Autoanti-P
ISBT symbol of LUKE
LKE
Luke is associated with _____
Renal carcinoma
Where is Luke expressed at?
Cord cells
Luke reacts to what?
All RBCs except P1, P2, PkP
Where is PX2 antigen present in?
Individuals reacted with p phenotype
Cord cells
In the Lewis system, when a phenotype changes to Le(a-b-), what may be the cause/s?
Pregnancy
Cancer
Alcoholic cirrhosis
Viral infections
Parasitic infections
