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IMMUNOHEMATOLOGY - Lec > Other Common Blood Groups > Flashcards

Other Common Blood Groups Flashcards

1
Q

ISBT number of Le

A

007

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2
Q

How is the Lewis system unique?

A

It is intrinsic in the glycosphingolipids

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3
Q

Chromosome and location of Lewis group

A

Chromosome 19
19p13.3

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4
Q

Lewis group is resistant to what enzymes?

A

Ficin
Papain
DTT
Glycin-acid EDTA

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5
Q

Lewis phenotype that is found at 10-40% of the Asian population

A

Le (a+b+)

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6
Q

Le phenotype that is an ADH secretor

A

Le (a-b+)

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7
Q

Le (a-b-) is common among _____

A

Black people

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8
Q

What is the enzyme that the Lewis system produces?

A

a1,4-L-fucosyltransferase

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9
Q

The most common antibody encountered from the Lewis system

A

Anti-Leª

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10
Q

Lewis antibodies are made by individuals with what phenotype?

A

Le(a-b-)

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11
Q

Glycolipids are detectable after ___ days since birth

A

10

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12
Q

Le non-secretors presents what phenotype at birth?

A

Le(a-b-)

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13
Q

Le^ab is formerly known as ___

A

Le^x

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14
Q

What is the precursor of the p1 antigen?

A

Type 2 oligosaccharide chain

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15
Q

P1PK blood group can be found where?

A

Platelets, epithelial cells, fibroblasts

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16
Q

What is the only blood group system that ia not manufactured by the RBCs

A

Lewis system

17
Q

ISBT number of P1PK

A

003

18
Q

ISBT number of Globoside system

A

028

19
Q

ISBT number of globoside collections (Luke-LKE)

A

209

20
Q

Phenotypes expressed by an individual with Globoside BGS

A

P, PX2

21
Q

Where are the P1Pk gene and A4GALT gene located at?

A

Chromosome 22, position 22q13.5

22
Q

Where is the location of Globoside, B3GALNT1 gene?

A

Chromosome 3, position 3q25

23
Q

P1Pk antibody produced by individuals with null phenotypes

A

Anti-P1Pk

24
Q

Anti-P1Pk antibody may cause ____

A

HTR and HDFN

25
Q

A naturally occuring IgM present on Pk individuals

A

Alloanti-P

26
Q

Alloanti-P reacts at what temperature?

A

37°C

27
Q

A cold reacting IgG antibody that is associated with paroxysmal cold hemoglobinuria

A

Autoanti-P

28
Q

ISBT symbol of LUKE

A

LKE

29
Q

Luke is associated with _____

A

Renal carcinoma

30
Q

Where is Luke expressed at?

A

Cord cells

31
Q

Luke reacts to what?

A

All RBCs except P1, P2, PkP

32
Q

Where is PX2 antigen present in?

A

Individuals reacted with p phenotype

Cord cells

33
Q

In the Lewis system, when a phenotype changes to Le(a-b-), what may be the cause/s?

A

Pregnancy
Cancer
Alcoholic cirrhosis
Viral infections
Parasitic infections

IMMUNOHEMATOLOGY - Lec (8 decks)

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