Revision Of Acquired Flashcards
What do chemokines do
Chemotaxis of Eg neutrophils,monocytes to infected tissue for inflammation
What do cytokines mainly do for inflammation
Increase endothelial permeability
Where do b and T cells develop into naive lymphocytes (before clonal selection)
Bone marrow B cells
Thymus T cells
Both primary lymphoid organs
What happens for differentiation in lymph nodes
Apc get attracted via chemokines to then present the antigens to tcr or antigens stay free for bcr
How many immunoglobulin chains are on antibodies/bcr
4 2l and 2H
How do antibodies bind to antigens
Non covalently via their CDr/hv regions
How many ig domains on light chains and what’s the structure
2
Vl is 2 beta sheet domains linked to vh beta sheets via disulfide bonds
How many ig domains consisting of 2 b sheets each are on heavy chain
4 or 5
1 x vh
3 or 4 ch
What is FAB
Antigen binding region
How many HV/CD-R regions are on each of vh and vl
3 each so 12 in total on antibody
What determines affinity/binding of ag epitope
The cdr HV regions
What does the constant FC region function
It allows activation of effector cells like neutrophils, eosinophils, mast cells via their fc receptors
And complement activation
How many aa makes up an ig domain Eg vh
110 aa
Why does isotope difference cause different effector cell activation
Different fc CH regions
True or false. TCR are made of 2 glycoprotein polypeptide chains a and b
True
Is tcr a hetereodimer of a and b glycoprotein chains
Yes
How many ig domains are on tcr
4 (Va,vb,ca,cb)
How many CD-R/HV regions in Va and vb of tcr
3 each
Which chromosome determines MHC/hla
6
How are hla a b and c different as all are MHC 1 molecules
All have a different a chain gene encoding A1,2,3 with many alleles (polymorphic)
Is MHC 1 a hetereodimer
Yes a with B2 microglobulin
How many genes for microglobulin B2 are there
1
What does many alleles for a chain gene in MHC cause
Different peptide clefts A1,a2
How are A1 and a2 different from ig domains
Also have a helixes unlike the rest
Which MHC binds smaller peptides 8-10 aa long
MHC 1- presents to CD8 cells
MHC II is an a and b heterodimer like tcr, what parts are the polymorphic peptide cleft which presents to CD4
A1 and B1
What types of genes are for MHC II
Hla dp a gene
Hla dp b gene
Hla dq a gene
Hla dq b gene
Hla dr a gene
Hla dr b gene
Are a2 and B2 on MHC II ig like
Yes
The peptide cleft is the same as MHC 1 with a helixes
