Revision Of Acquired Flashcards
What do chemokines do
Chemotaxis of Eg neutrophils,monocytes to infected tissue for inflammation
What do cytokines mainly do for inflammation
Increase endothelial permeability
Where do b and T cells develop into naive lymphocytes (before clonal selection)
Bone marrow B cells
Thymus T cells
Both primary lymphoid organs
What happens for differentiation in lymph nodes
Apc get attracted via chemokines to then present the antigens to tcr or antigens stay free for bcr
How many immunoglobulin chains are on antibodies/bcr
4 2l and 2H
How do antibodies bind to antigens
Non covalently via their CDr/hv regions
How many ig domains on light chains and what’s the structure
2
Vl is 2 beta sheet domains linked to vh beta sheets via disulfide bonds
How many ig domains consisting of 2 b sheets each are on heavy chain
4 or 5
1 x vh
3 or 4 ch
What is FAB
Antigen binding region
How many HV/CD-R regions are on each of vh and vl
3 each so 12 in total on antibody
What determines affinity/binding of ag epitope
The cdr HV regions
What does the constant FC region function
It allows activation of effector cells like neutrophils, eosinophils, mast cells via their fc receptors
And complement activation
How many aa makes up an ig domain Eg vh
110 aa
Why does isotope difference cause different effector cell activation
Different fc CH regions
True or false. TCR are made of 2 glycoprotein polypeptide chains a and b
True
