Antigen Processing And Presentation Flashcards
Where are antigens Eg viral protein presented on MHC 1 on all nucleated cells produced
Cytoplasm of cell / endogenous
What cleaves endogenous protein peptide in MHC 1 processing
Proteasome
Where do endogenous peptides cleaved by proteasomes go to
ER via the tap transporter
What can proteasomes receive signals from which cause they to further cleave peptides to better fit MHC 1
Cytokines
What part of TAP peptide loading complex covers peptide cleft of MHC I when in ER
Calreticulin
When the peptide endogenous goes through tap. What removes calreticulin from peptide Cleft so peptide can bind
Tapasin
What change does peptide binding to MHC I make
Conformational change
Through what does MHC I and peptide move to surface
Golgi
How do exogenous antigen peptides get into cell for MHC II presentation
Endocytic vesicles
Where and how is peptide cleaved in MHC II process
In a phagolysosome by acidic proteases ph4
Where is MHC II produced form which then leaves via vesicles
ER
What does MHC II have which stops peptide binding in ER
Invariant chain
What degrades the invariant chain and what does it leave
Acidic enzymes in the endosome MHC II is in
Leaves a CLIP which is still bound to peptide cleft
What does hla dm do so antigens which have fused with the endosome can bind to peptide cleft
Hla dm removes CLIP so peptides can bind
Do MHC only present peptides in a diseased state Eg peptides from viruses
No. They constantly present self peptides but these don’t evoke a T cell response
