revision ECM

Question 1

ecm

Answer 1

found in all metazoans
made of carbs and proteins - fibrillar and non-fibrillar
all components interact together to give mechanical strength and affects cell differentiation and division
found basal to epithelium and the basal lamina

Question 2

composition of the basement membrane

Answer 2

type IV collagen
laminins
perlecan

Question 3

epidermolysis bullosa

Answer 3

a gene mutation results in abnormalities in all 3 chains of laminin 5

Question 4

collagen

Answer 4

glycine found in interior -0 small enough

comprises of 3 alpha chains forming a triple helix

Question 5

vitamin C

Answer 5

required for the functioniung opf prolyl and lysyl hydroxylases

Question 6

diameter of collagen fibre

Answer 6

3um

Question 7

amino acids in the a-helical regions of elastin

Answer 7

alanine and lysine

Question 8

core of elastin

Answer 8

made of elastin, fibrillin, microfibrils

Question 9

extent of stretch of elastin determined by…

Answer 9

interwoven-ness of the elastin molecules

Question 10

links between elastin molecules

Answer 10

covalent

Question 11

what type of molecule is laminin

Answer 11

glycoproteins

Question 12

what is the gel like substance that makes up proteoglycans that resists compression when hydrated

Answer 12

GAGs
joined to protein core to give proteoglycans
long unbranched sugars made of repeating disaccharides

Question 13

hyaluronan

Answer 13

single unsulfated GAG chain
doesn’t associate with a protein core
just a carb chain

Question 14

aggrecans

Answer 14

major cartilage component

made of core protein, link protein, chondroitin sulfate, keratan sulfate and hyaluronan