Revision

Question 1

Where are MHC Class II and II found? HLA?

Answer 1

Class I: found on all nucleated cells (HLA-A, HLA-b, HLA-C)

Class II: found on dendritic cells, B cells, macrophages (HLA-DR, HLA-DQ, HLA-DP)

Question 2

What kind of microbes do the two MHC classes present peptides from?

Answer 2

Class I: intracellular

Class II: extracellular

Question 3

Dendritic cells: location, present antigens to

Answer 3

• Lymph nodes, mucous membranes, blood

- Naive T cells

Question 4

Langerhans’ cells: location, present antigens to

Answer 4

• Skin

- Naive T cells

Question 5

Macrophages: location, present antigens to

Answer 5

• Various tissues

- Effector T cells

Question 6

B cells: location, present antigens to

Answer 6

• Lymphoid tissues

- Effector T cells, Naive T cells

Question 7

Which T cells are the MHC classes recognised by?

Answer 7

Class I: CD8+

Class II: CD4+

Question 8

Endogenous and exogenous antigen processing pathways

Answer 8

Adaptive immunity slide 13

Question 9

HIV slow and rapid progressors

Answer 9

Slow progressor MHC molecules present key peptides for the survival of the virus