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Review 4 Lipoproteins Flashcards

1
Q

Chylomicron

  1. formed
  2. main lipid
  3. apo proteins
  4. function
A
  1. intesine
  2. TAG
  3. B- 48 (ACE)
  4. Transports dietary TAG to adipose and other tissue
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2
Q

Chylomicron Remnant

  1. formed
  2. main lipid
  3. apo proteins
  4. function
A
  1. Remnant
  2. TAG
  3. B-48 (ACE)
  4. Delivers remaining dietary TAG to liver
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3
Q

VLDL

  1. formed
  2. main lipid
  3. apo proteins
  4. function
A
  1. Formed in liver
  2. TAG
  3. B-100 ACE
  4. endogenously synthesized TAG to adipose tissue
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4
Q

IDL-VLDL remnant

  1. formed
  2. main lipid
  3. apo proteins
  4. function
A
  1. formed via processing of VLDL in the circulation
  2. Tag and Cholesterol
  3. B 100 E
  4. Delivers remaining TAG and cholesterol to liver
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5
Q

LDL

  1. formed
  2. main lipid
  3. apo proteins
  4. function
A
  1. formed via processing of IDL in circulation
  2. Cholesterol
  3. B-100
  4. Delivers cholesterol to the liver and other cells
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6
Q

HDL

  1. formed
  2. main lipid
  3. apo proteins
  4. function
A
  1. formed in the liver
  2. cholesterol
  3. A’s C,E
  4. Transports the CEs to the liver
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7
Q

Chylomicrons transport what type of lipid

A

dietary (Exogenous)

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8
Q

VLDL, IDL, LDL transport what type of lipid

A

synthesized (endogenous)

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9
Q

What is Apo-C2 a cofactor for?

A

lipoprotein lipase

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10
Q

What is Apo-A1 a cofactor for?

A

lecithin: cholesterol acyltransferase

LCAT

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11
Q

Apo E Ligand to what receptor

A

Remnant receptor

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12
Q

Apo B-100 Ligand to what receptor

A

LDL Receptor

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13
Q

Apo A-1 ligand to what receptor

A

HDL receptor

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14
Q

What structural protein makes up chylomicrons?

A

B-48

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15
Q

What structural protein makes up VLDL and LDL?

A

B-100

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16
Q

What structural protein makes up HDL?

17
Q

What are 4 steps of Statins?

A
  1. Inhibit HMC-CoA reductase
  2. Increases LDL receptors
  3. Increases removal of cholesterol
  4. decreases cholesterol in the blood
18
Q

Do statins work if LDL receptors not there?

19
Q

How do high cholesterol levels affect synthesis of LDL receptors?

A

Down-regulates (decreased synthesis)

Metabolism (13 decks)

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