Review Flashcards
What is the mechanism of action of dapagliflozin?
SGLT2 inhibitor (competitive reversible inhibition)
What is the mechanism of action of Abciximab?
Inhibits GPIIb and GPIIIa receptors
What is the adverse drug reaction of taking methotrexate and NSAIDs simultaneously?
NSAIDs bind very strongly to proteins like albumin so can displace methotrexate leading to INCREASED plasma concentration of METHOTREXATE
What are some adverse drug reactions of Amlodipine?
What type of drug is it?
Ankle swelling
Flushing
Headaches
Dihydropyridine Calcium Channel blocker
What is the mechanism of action of Naloxone?
Competitive opioid receptor antagonist
What are the 4 classes of drug given as secondary prevention of MI after having an MI?
ACE inhibitor
Aspirin
Beta blocker
Statin
What are the steps of management of status epilepticus?
IV lorazepam
IV lorazepam again after 5mins
IV phenytoin, sodium valproate or levetiracetam
IV phenytoin, sodium valproate or levetiracetam after another 5 mins (different one to previous)
IV barbiuratets or anaesthesia
What diuretic increases the risk of gout?
Thiazides:
-bendroflumethiazides
-indapamide
What are some serious side effects of co-careldopa?
Inability to control compulsive behaviours:
-compulsive shopping
-gambling
-hhypersexuality
What is the recommend first treatment for Giant Cell Arteritis?
Glucocorticoids
Prednisolone
What is the mechanism of action of fomoterol?
When is it given?
Long Acting Beta Agonist (LABA)
Asthma
What advice should be given when coming of corticosteroid medications?
Titrate the dose down slowly using the advice of a clinician
How many half lives are needed for plasma steady state concentration to be reached for a drug with first order kinetics?
4-5 half lives
According to nice guidelines, what medication should be added to improve a patients asthma?
What class of drug is this?
Montelukast
Leucotriene receptor antagonist
What antiemetic causes extra pyramidal symptoms like Parkinsonism??
Metoclopramide
