Lecture 21 - Abx

Question 1

What antibiotic would you give to a pregnant woman with a Lower UTI and why?

Answer 1

Nitrofurantoin for 7 days(NOT TRIMETHOPRIM)

Don’t give trimethoprim since its a folate antagonist by inhibiting bacterial dihhydrofolate REDUCTASE)

Question 2

What class of drug is gentamicin?

Answer 2

Aminoglycoside (protein synthesis inhibitor)

Question 3

What are the dangerous side effects of gentamicin and is the reason we need to closely monitor patients?

Answer 3

Nephrotoxic
Ototoxic

Question 4

What is the drug-drug interaction between trimethoprim and methotrexate?

Answer 4

They are both folate antagonists so cause neutropenia due to bone marrow suppression

Question 5

What is Murphy’s sign?

Answer 5

Palpate RUQ then patient inhales causing pain

Indicates acute cholecystitis

Question 6

What is the mechanism of action of amoxicillin?

Answer 6

Beta lactam

Cell wall synthesis inhibitor

Question 7

What is CURB-65?

Answer 7

Confusion
Urea > 7mmol
Resp rate > 30
BP SBP<90 or DBP < 60
Over 65

Question 8

What drugs are given if CURB65 is above 3?

Answer 8

Co-amoxiclav and Clarithromycin