Review #1 Flashcards
Most common cause of non-immune fetal hydrops
Monosomy X
Ultrasound features of Turner Syndrome
Coarctation of the aorta, short long bones, cystic hygroma
Risk of pregnancy for someone with Turner Syndrome
Aortic dissection
Cancers associated with BRCA
Prostate (BRCA1), pancreatic, melanoma (BRCA2), endometrial, gastric, biliary, colorectal
Peutz-Jeghers gene
STK11
Peutz-Jeghers cancers
Colon and rectal, pancreatic, stomach, small intestine
Li-Fraumeni gene
TP53
Li-Fraumeni cancers
Sarcoma, brain, leukemia, adenocortical
Cowden gene
PTEN
Cowden cancers
Endometrial, thyroid
Hereditary nonpolyposis colorectal cancer genes
MLH1, MSH1, MSH6, PMS2
HNPCC cancers
Colon, endometrial, gastric
CHEK2 cancers
Colorectal, prostate, male breast, thyroid, kidney
PALB2 cancers
Pancreatic, prostate
ATM cancers
Leukemias and lymphomas
Oligohydramnios
AFI < 5 cm, MVP < 2 cm
Polyhydramnios
AFI > 24 cm, MVP > 8 cm
AFI that warrants amnioreduction
> 35 cm
Indication for antibiotics in HSG
Hydrosalpinx
Risk of heterotopic pregnancy in IVF
1/100
Angelman vs Prader-Willi genetics
Imprinting
Angelman - maternal
Prader-Willi - paternal
Treatment for Group A strep
Penicillin G and clindamycin
Antibiotics for fourth degree laceration?
No
History indicated cerclage indication
One or more second trimester loss without labor or abruption
History indicated cerclage timing
12-14 wga
Ultrasound indicated cerclage indications
Singleton, history of preterm birth, CL <25 mm
Ultrasound indicated cerclage timing
16-23 wga
Physical exam indicated cerclage indications
Dilated cervix at 16-23 wga
Primary syphilis symptoms
Painless chancre that develops about 21 days after infection and resolves 3-6 weeks later
Secondary syphilis symptoms
2-10 weeks after chancre, adenopathy, constitutional symptoms, doffuse papular rash involving palms and soles, condyloma lata in moist folds
Tertiary syphilis symptoms
Aortitis, neurosyphilis, gummas
Early syphilis treatment
Penicillin G 2.4 million units IM once
Late syphilis treatment
Penicillin G 2.4 million units IM weekly for 3 weeks
Couvaire uterus
Caused by blood flow into myometrium during severe placental abruption
Tumor marker associated with granulosa cell tumor
Inhibin
Muscles potentially torn in second degree laceration
Pubococcygeus, bulbocavernosus, transverse perineal
Chromosomes of BRCA 1, 2
17 and 13
Stage egg is frozen for social cryopreservation
Mature oocyte: haploid cell with one polar body
Treatment for prolactinoma
Dopamine agonist: cabergoline (less side effects) or bromocriptine
Single agent chemo for nonmetastatic GTN
Methotrexate or actinomycin D
Contraindication to Elagolix
Pregnancy, elevated LFTs
Isolated ultrasound finding that confers greatest risk for trisomy 21
Thickened NT
What type of gene is HER2?
Oncogene, encodes erbB2 tyrosine kinase, a constituively active protein that amplifies cell replication
Mechanism of trastuzumab
Monoclonal antibody to inactivate HER2/neu receptor tyrosine kinase
Inheritance pattern of BRCA
Autosomal dominant
HPV, type of virus
Double stranded DNA
Adverse effect of trastizumab
Cardiotoxicity
Drug used in postmenopausal women with ER/PR+ breast cancer
Anastrozole
Anastrozole mechanism
Aromatase inhibitor that prevents conversion of androgens to estrogen
SERM used in prevention of postmenopausal osteoporosis
Raloxifene