Reversals

Question 1

Neostigmine

Answer 1

Concentration: 1 mg/ml
Mechanism of Action: Anticholinesterase
Dose: 0.02-0.07 mg/kg
Onset: 1-5 min
Peak: 5 min
Duration: 60-120 min
T1/2B: 60-120 min
Elimination: Hep/Plasma Cholinesterase

Question 2

Glycopyrrolate

Answer 2

Concentration: 0.2 mg/ml
Mechanism of Action: Antimuscarinic
Dose: 0.2 mg per 1 mg of neostigmine
Onset: < 1 min
Peak: 5 min
Duration: 2-3 hours
T1/2B: 80 min
Elimination: Hep/Renal