Reuben - Hemato

Question 1

formed elements

Answer 1

RBCs, WBCs, plasma(platelets)

Question 2

Granulocytes

Answer 2

BEN

• Basophils - involved in releasing histamine in immune reactions.
• Eosinophils - destroys larger parasites and is involved in immune reactions.
• Neutrophils - phagocytose and engulf invading bacteria.

Question 3

Monocytes

Answer 3

becomes tissue macrophages. Phagocytose invading material and damaged cells.

Question 4

hierarchic and stochastic

Answer 4

same thing as asymmetrical and symmetrical

Question 5

Aplastic Anemia

Answer 5

Disease in which the hematopoietic stem cells of the bone marrow are not working properly. Therefore there will be severely less white and red blood cells. Under microscope it will just look like lipid droplets. Lack of energy makes sense because lack of RBCs. More prone to infection makes sense because lack of WBCs - however there will be no pus. Caused by destruction of uncommitted stem cells.

Question 6

Till and McColough Experiment

Answer 6

You can irradiate the bone marrow cells of a mouse and then inect it with another mouses bone marrow cells and you will see the mouse will live.

Question 7

Pure red blood cell aplasia

Answer 7

When only the red blood cells don’t form. It is a mutation in it’s progenitor.

Question 8

Agranulocytosis

Answer 8

Lack of only white blood cells. Mutation in it’s pregenitor cells.

Question 9

Cytokines and Interleukins

Answer 9

These guys are responsible for telling the stem cell to differentiate and into what. For instance, if one cytokine is expressed perhaps a neutrophil will be made but if a different cytokine is expressed then maybe an eosinophil is made.

Question 10

What are some specific surface receptors/cytokines for macrophage development

Answer 10

Cd34 in myeloid
Cd33 and CD14 in monocyte
- these are all lost once it becomes a macrophage