Retinal Physiology Flashcards
PRs are slightly depolarized relative to a typical neuron. What is the resting membrane potential of a PR?
-50mV
In the dark, what 2 things happen to PRs?
- Release glutamate
2. Depolarized
In the light, what 2 things happen to PRs?
- No glutamate released
2. Hyperpolarized
What % of rhodopsin must be bleached to have a critical number of sodium channels closed?
10%
PRs show what type of potential?
Graded potential - degree of PR hyperpolarization is related to intensity of stimulus
PRs synapse with what 2 inhibitory cells in the OPL?
- Bipolar Cells
2. Horizontal Cells
What two cells send retinal info horizontally? Are these cells excitatory or inhibitory?
Horizontal and amacrine cells
- inhibitory
Lateral connections provide feedback transmission of information via what pathway?
Centrifugal pathway (from gang. cells to PRs)
Horizontal cells receive input from what cell?
One or more PR
Horizontal cells send information to what cell?
Bipolar cells - may also be innervated directly by other PRs
What inhibitory neurotransmitter do horizontal cells release in response to DEPOLARIZATION of PRs?
Gaba
H1 Horizontal cells primarily receive input from what PR?
M and L Cones
This type of horizontal cell regulates adaptation and spatial responses of cones and bipolar cells
H1
T/F: H1 cells connect to cones in its dendritic field and rods at its most distal end
True
H2 horizontal cells receive input from all 3 types of cones. Do they connect to rods?
No, do not connect to rods
What 2 types of cells show a graded response?
PRs and Horizontal Cells
PRs and Horizontal Cells both HYPERPOLARIZE in response to light. What is this called?
Sign-conserving synapses
This is the region of visual space that makes a neuron change its firing under the presence of a certain visual stimulus.
Retinal receptive field
A bipolar dendrite synapses with what 2 cells?
PRs and Horizontal cells
Dendrite = BPH, dicks
A bipolar axon synapses with what 2 cells?
Ganglion, Amacrine Cells
Axon = BAG