Respiratory Viruses Flashcards
Describe myxovirus in terms of alternate names, viral structure, symptoms, and transmission
Aka: Influenza virus
Structure: enveloped RNA virus (8 strands )
Symptoms: fever, runny nose, sore throat, mild cough, aches, muscle pain, generalized malaise, possible N/V in children
Transmission: droplets
What has a higher mortality rate viral PNA or secondary bacterial PNA associated w/ myxovirus
Viral PNA has higher mortality rate (10%) when compared to secondary bacterial PNA
What 2 surface antigens do we care about with myxovirus
Hemagglutinin (H) and Neuroaminidase (N) used for attachment and virulence
How do the surface antigens (H and N) change in myxovirus
gene recombination and gene mutation
Out of the 3 antigenic types of myxovirus what types are antigenically stable
Types B and C are stable
Type A have lots of recombinations and mutations (avian, swine, human subtypes)
Can Rx be used for myxovirus infection
yes within the first 48 hrs to be effective
How is the vaccine made for the flu
it is made with the 4 most common or significant antigens moving toward the USA
Describe Rhinovirus in terms of viral structure, disease caused, symptoms, transmission
Structure: RNA virus
Disease: most prevalent agent of the common cold
Symptoms: runny nose, sneezing, sore throat, cough, fever is less common
Transmission: droplets and contacts
Describe Respiratory syncytial virus in terms of other names,viral structure, disease caused, symptoms, and transmission
Aka: Human orthopneumovirus
Structure: RNA virus
Disease: can cause severe infection in children
Transmission: droplets and contacts
Describe Corona virus in terms of viral structure, recent virulent variants, disease caused, symptoms, and transmission
Structure: RNA virus
Disease: 2nd most common agent of colds, COVID 19
Highly virulent variants: , SARS-CoV1, MERS-CoV, and SARS-CoV2
Symptoms: fever, cough, SOB
Transmission: droplets
What is the name of the disease caused by SARS-CoV2
COVID 19
Where does the antigen spike of SARS-CoV2 attach
ACE-2 and NRP-1 (neuropilin 1) receptors
What is the affect of SARS-CoV2 attaching to NRP-1
it silences the bodys pain signaling pathways to allow spread w/o inflammatory pain
The pathology of SARS-CoV2 is d/t what
- higher exposure = higher virulence
- bradykinin storm causes blood vessels to expand and become leaky and leading to swelling and decreasing O2 uptake
Describe parainfluenza virus in terms of viral structure, and disease caused
Structure: enveloped RNA virus
Disease: croup, bronchitis, cold-like
