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MAP II Final > Respiratory System: Gas Exchange and Gas Transport in the Blood > Flashcards

Respiratory System: Gas Exchange and Gas Transport in the Blood Flashcards

1
Q

What is the process of randomly moving molecules making their way back and forth across respiratory membrane?

A

diffusion

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2
Q

What is termed the molecular impact on surface?

A

pressure

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3
Q

What is the term for the pressure exerted by each gas?

A

partial pressure

    • multiple gases in the air
    • rate of diffusion directly related to partial pressure of gas
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4
Q

Partial pressure equation

A

concentration of dissolved gas / solubility coefficient

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5
Q

Direction of net diffusion depends on what? (6)

A
  • pressure difference
  • solubility of gas in fluid
  • cross-sectional area of fluid
  • distance gas must diffuse
  • molecular weight of the gas (smaller = better)
  • temperature of fluid
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6
Q

Diffusion equation

A

(change in pressure x area x solubility coefficient) / (distance to diffuse x square root of molecular weight)

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7
Q

Do respiratory gases diffuse across a membrane easily?

A

yes

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8
Q

What is a limiting factor to rate of diffusion?

A

water

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9
Q

Rate of diffusion thru tissue is similar to what?

A

diffusion thru water

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10
Q

What respiratory gas is constantly being absorbed from alveoli?

A

O2

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11
Q

What respiratory gas is constantly diffusing from blood to alveoli?

A

CO2

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12
Q

What is humidified in the respiratory tract?

A

H2O

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13
Q

How many mmHg of O2 in alveoli?

A

104 mmHg

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14
Q

Amount of O2 in alveoli is controlled by what? (2)

A
  • rate of absorption by pulmonary capillaries

- rate of O2 entry into alveoli via ventilation

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15
Q

How many mmHg of CO2 in alveoli?

A

40 mmHg

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16
Q

Amount of CO2 in alveoli is controlled by what? (2)

A
  • rate of excretion by pulmonary capillaries

- rate of alveolar ventilation

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17
Q

Increase expiration equals what?

A

increase expiration = decrease in CO2 = decrease in PCO2

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18
Q

Amount of PO2 in venous blood of capillary?

A

40 mmHg

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19
Q

Amount of PCO2 in venous blood of capillary?

A

45 mmHg

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20
Q

The amount of O2 in the alveoli can never exceed what?

A

149 mmHg @ sea level if breathing normally

– because that is the max PO2 in the system after it has become humidified

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21
Q 
Diffusion coefficients for the following:
O2
CO2
CO
N2
He
A 
O2 = 1.0
CO2 = 20.3
CO = 0.81
N2 = 0.53
He = 0.95
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22
Q

Alveolar air replacement – how much new air goes into the alveoli with each breath?

A

350 mL

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23
Q

What fraction of alveolar air is replaced by new air with each breath?

A

1/7

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24
Q

Do we have a quick exchange of O2/CO2?

A

No – it is a more tempered response to partial pressures

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25
Q

What causes diffusion to be rapid?

A

large surface area of respiratory membrane w/ small amount of blood spread throughout

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26
Q

Pulmonary capillaries have a large or small diameter?

A

small diameter

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27
Q

What 4 factors is diffusion affected by?

A

a. thickness of membrane
b. surface area of respiratory membrane
c. diffusion coefficient
d. pressure difference across membrane

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28
Q

The volume of gas that will diffuse thru the membrane from the lungs to the blood each minute for a partial pressure difference of 1 mmHg?

A

Diffusion capacity

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29
Q

Diffusion capacity of oxygen at rest? During exercise?

A

Rest: ~ 230 ml O2/min
Exercise: max 3x diffusion capacity

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30
Q

Diffusion capacity of carbon dioxide at rest? During exercise?

A

Rest and exercise: increase proportionately to O2 given that CO2 has a diffusion coefficient > 20x of O2

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31
Q

Q =

A

perfusion

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32
Q

Va =

A

ventilation

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33
Q

Va/Q = normal

A

Va for an alveolus is normal and Q is normal for the same alveolus

34
Q

Va/Q = 0

A
  • Va is zero and there is blood flow

- No gas exchange

35
Q

Va/Q = infinity

A
  • Va is adequate and there is no blood flow

- No gas exchange

36
Q

What do bronchial arteries supply?

A

supply deep tissues of lungs and do not come into contact w/ lung air

37
Q

Blood from the bronchial arteries to the deep tissues of the lungs returns to the left atrium via which veins?

A

pulmonary veins

38
Q

What happens when the blood returns from the lungs to the left atrium? Drops PO2 to levels to what?

A

oxygenated blood mixes with unoxygenated blood and drops PO2 to 95 mmHg

39
Q

How much PO2 in the interstitial fluid surrounding cells?

40
Q

How much PO2 in cells?

A

23 mmHg (O2 diffuses from cells to interstitial fluid)

41
Q

How much PO2 in venous return?

42
Q

How much CO2 flow out of the cell –> interstitial fluid –> capillaries?

43
Q

Is there a less pressure difference to cause CO2 diffusion than O2 diffusion?

44
Q

How much PCO2 in cells?

45
Q

How much PCO2 in interstitial fluid?

46
Q

How much PCO2 in the capillaries?

47
Q

How much PCO2 in alveolar air?

48
Q

Decreased blood flow to interstitial fluid _______ PCO2 in fluid

49
Q

Increase in blood flow at interstitial fluid _______ PCO2 in fluid

50
Q

Increase in metabolism _______ interstitial fluid PCO2 at all blood flow levels

51
Q

How much oxygen does hemoglobin transport from lungs to tissues (hemoglobin saturation)?

52
Q

What does the dissociation curve illustrate?

A

% of hemoglobin saturated by O2 @ any given point along transport route

53
Q

When O2 binds with hemoglobin, is PCO2 high or low?

54
Q

When O2 is released from hemoglobin, is PCO2 high or low?

55
Q

What causes the dissociation curve to shift to the RIGHT?

A

(more O2 to tissues):

a. increase blood acidity (lower pH)
b. increase CO2
c. increase temperature
d. increase BPG
e. Bohr effect: increase in H+ and CO2 shifts curve to the right
f. exercise

56
Q

What causes the dissociation curve to shift to the LEFT?

A

(less O2 to tissues):

a. Higher pH

57
Q

O2 leaving the lungs has partial pressure of what?

58
Q

O2 leaving the tissues has a partial pressure of what?

59
Q

Hemoglobin saturation percentage of O2 leaving the tissues?

60
Q

How many grams of hemoglobin can carry 20 ml O2 in 100 ml blood?

61
Q

Normal conditions of O2 release from hemoglobin to tissues?

A
  1. 4 ml O2 to tissues

- - leaves tissues with 14.4 ml O2

62
Q

How much O2 is left in tissues per 100 ml blood?

63
Q

How much does interstitial fluid PO2 drop during strenuous exercise?

A

40 mmHg –> 15 mmHg

64
Q

How much O2 is delivered to the tissues during strenuous exercise?

A

net delivery of 15 ml to tissues ( 3x the normal amount of O2 delivered)

65
Q

How much does PO2 drop in alveoli?

A

104 mmHg –> 60 mmHg

66
Q

How much does hemoglobin saturation drop in alveoli?

A

97% to 89%

67
Q

PO2 of tissues?

68
Q

PO2 in alveoli can increase to what?

69
Q

hemoglobin saturation cannot increase higher than what percentage?

70
Q

Carbon monoxide poisoning?

A
  • CO combines with Hgb @ same location as O2

- CO has higher affinity for Hgb than O2

71
Q

What amount of PCO is lethal?

72
Q

What amount of CO2 per 100 ml of blood is transported from tissues to lungs?

73
Q

Amount of CO2 in plasma?

74
Q

CO2 combines with H2o to form what?

A

carbonic acid

75
Q

How much CO2 per 100 ml of blood?

76
Q

Normal range of CO2 in tissues?

77
Q

Normal range of CO2 in arterial blood?

78
Q

Respiratory Exchange Ratio (RER) compares what?

A

CO2 output to O2 intake

79
Q

Normal uptake of O2?

A

5 ml O2 is taken up by the tissues and 4 ml of CO2 transported from tissues to lungs

80
Q

RERE equation

A 
RER = (rate of CO2 output) / (rate of O2 uptake)
Normal values:
a. Carbs: R = 1.0
b. Fats: R = 0.7
c. Carb/Fats/Protein: R = 0.85

MAP II Final (9 decks)

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