Respiratory system Flashcards
What is pulmonary ventilation?
Breathing of air into/out of the lungs
What are the 2 types of gaseous exchange?
External respiration
Internal respiration
What is external respiration?
Gaseous exchange of oxygen and carbon dioxide between the lungs and blood
What is internal respiration?
Gaseous exchange of oxygen and carbon dioxide between the blood and muscles/tissues
What is cellular respiration?
In mitochondria, oxygen is used to break down glucose into carbon dioxide and water during aerobic respiration
Which muscles contract in inspiration at rest?
External intercostal muscles
Diaphragm
Which extra muscles contract in inspiration during exercise?
Sternocleidomastoid
Scalenes
Which muscles contract in expiration at rest?
None
The diaphragm and external intercostals passively relax
Which extra muscles contract in expiration during exercise?
Internal intercostal muscles
External/internal obliques
Rectus abdominus
What 2 things can muscles do?
Actively contract or passively relax
What does muscle contraction and relaxing cause?
Movement of the ribs, sternum and abdomen either up and out or down and in
What does the movement of the ribs, sternum and abdomen cause?
The volume of the thoracic cavity to either increase or decrease
What happens when the volume of the thoracic cavity is decreased?
Lung air pressure increases causing expiration
What happens when the volume of the thoracic cavity is increased?
Lung air pressure decreases causing inspiration
Which ones of these are active? Inspiration at rest Expiration at rest Inspiration during exercise Expiration during exercise
Inspiration at rest
Inspiration during exercise
Expiration during exercise
Why is expiration at rest the only passive process?
It is the only one where no muscles actively contract, all muscles just passively relax
What % of oxygen is carried in red blood cells as oxyhaemoglobin?
97%
What % of oxygen is carried in blood plasma?`
3%
What % of carbon dioxide is carried in haemoglobin as carbaminohaemoglobin?
23%
What % of carbon dioxide is dissolved in blood plasma?
7%
What % of carbon dioxide is combined with water in red blood cells as carbonic acid?
70%
What is haemoglobin?
A protein molecule in red blood cells which contains 4 haem groups that can each carry 1 oxygen molecule
What process does gaseous exchange depend on?
Diffusion
What is diffusion?
Movement of gases from an area of high pressure to an area of low pressure down the diffusion gradient
What is a diffusion gradient?
The difference between the high and low pressure
What happens to diffusion as the diffusion gradient increases?
More diffusion occurs and at a quicker rate.
Therefore, more gaseous exchange of oxygen and carbon dioxide takes place,.
What is the definition of partial pressure?
The pressure a gas exerts within a mixture of gases.
What type of blood has a high partial pressure of oxygen?
Oxygenated
What type of blood has a low partial pressure of oxygen?
Deoxygenated
What type of blood has a high partial pressure of carbon dioxide?
Deoxygenated
What type of blood has a low partial pressure of carbon dioxide?
Oxygenated
What direction does carbon dioxide go between the alveoli and blood?
From blood to alveoli
lower pp in alveoli
What direction does oxygen go between the alveoli and blood?
From alveoli to blood
lower pp in blood
What direction does carbon dioxide go between blood and respiring tissues?
From respiring tissues to blood
lower pp in blood
What direction does oxygen go between blood and respiring tissues?
From blood to respiring tissues
lower pp in respiring tissues
What dissociates/associates to the blood in external respiration?
Carbon dioxide dissociates and goes into alveoli
Oxygen associates to haemoglobin
What dissociates/associates to the blood in internal respiration?
Carbon dioxide associates to blood
Oxygen dissociates and goes to muscles
What happens to external/internal respiration during exercise?
Both increase to increase the supply of oxygen to working muscles.
What happens to the oxygen dissociation curve during exercise?
Shifts right
Oxygen dissociates more easily to supply working muscles
How much oxygen dissociates into muscles at rest?
25%
Still 75% saturation
During exercise what happens to the blood returning to the lungs?
It is more deoxygenated as skeletal muscles are using more oxygen to release energy so more carbon dioxide is produced.
What happens to the association of oxygen at the alveoli during exercise?
Increases as the pp of oxygen in the alveoli is the same but it’s lower in the alveoli capillaries so the diffusion gradient is steeper.
What happens to the dissociation of carbon dioxide at the alveoli during exercise?
Increases as the pp of carbon dioxide in the alveoli is the same but it’s higher in the alveoli capillaries so the diffusion gradient is steeper.
What 4 factors shift the oxygen dissociation curve to the right during exercise?
Increased temperature (blood/muscle)
Decreased pp of oxygen in muscles
Increased pp of carbon dioxide in muscles
Bohr effect (decreased pH)
What is the definition of tidal volume?
Volume air expired/inspired in one breath
What is the definition of frequency?
Number of breaths in 1 minute
What is the definition of minute ventilation?
Volume of air inspired/expired in 1 minute
What is the average resting tidal volume?
500ml per breath
What is the average resting frequency?
12/15 per minute
What is the average resting minute ventilation?
6-7.5 Lmin
What is the TV during exercise (untrained)
2/3 L
What is the TV during exercise (trained)
Up to 3.5 L
What is the maximal frequency during exercise (untrained)
20-50 breaths per minute
What is the maximal frequency during exercise (trained)
60 breaths per minute
What is the maximal minute ventilation during exercise (untrained)
100-150 L per minute
What is the maximal minute ventilation during exercise (trained)
180-210 L per minute
Why does minute ventilation plateau during aerobic exercise?
Oxygen supply equals demand of muscles
Where is the respiratory control centre?
Medulla oblongata
Describe how respiratory control centre increases rate and depth of breathing
Sympathetic nervous system stimulates phrenic (diaphragm) and intercostal nerves to increase rate and depth of breathing
Describe how the respiratory control centre decreases rate and depth of breathing
Parasympathetic nervous system decreases stimulation of respiratory muscles to decrease rate and depth of breathing
What is another name for minute ventilation?
Pulmonary ventilation
What is another name for frequency?
Rate of breathing
What is another name for tidal volume?
Depth of each breath
What else does the respiratory control centre stimulate during exercise?
The additional muscles used in breathing during exercise
What receptors detect a need to increase pulmonary ventilation?
Baroreceptors (increase in blood pressure)
Proprioceptors (increase in motor movement)
Chemoreceptors (decrease in pH)