Respiratory Infections And Tumours Flashcards

1
Q

What is pneumonia?

A

Inflammation and consolidation of lung tissue due to an infectious agent

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2
Q

What bacterial pathogens can cause pneumonia?

A

S.pneumoniae causes 60-75%
M.pneumoniae causes 2-18%
H.influenzae causes 3-10%

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3
Q

What viral pathogens can cause pneumonia?

A

Influenza A causes 8%
Influenza B causes 1%
Adenovirus causes 1%

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4
Q

Wha fungal pathogens can cause pneumonia?

A

Pneumocystis jiroveci
Nocardia species
Cryptococcus
Murcormycosis

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5
Q

What are the symptoms of pneumonia?

A
Fever 
Chills 
Pleuritic chest pain 
Cough 
Purulent sputum 
Dyspnoea 
Confusion 
Headache 
Nausea 
Vomiting 
Abdominal pain 
Diarrhoea
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6
Q

What is the treatment of pneumonia?

A

Antibiotic treatment- unknown aetiology
Uncomplicated- aminopenicillin or benzylpenicilln or macrolide
Complicated- extended spectrum, antibiotic and macrolide

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7
Q

What is CURB-65?

A

This is a score that estimates mortality of pneumonia to help determine whether or not the patient should be in hospital
Confusion
Urea >7mM
Respiratory rate >30/min
Blood pressure diastolic <60mmHg or systolic <90mmHg
Older than 65 years

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8
Q

What is lung cancer?

A

Malignancy originating in the airways or lung parenchyma

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9
Q

What are the risk factors for lung cancer?

A
Smoking 
Environmental (second hand) tobacco smoke 
Asbestos 
Radon 
Arsenic 
Ionising radiation 
Haloethers 
Polycyclic aromatic hydrocarbons 
Nickel, chromium
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10
Q

What is the pathology of lung cancer?

A

Non small cell lung cancer (NSCLC)- squamous cell, adenocarcinoma, bronchoalveolar carcinoma
Small cell lung cancer (SCLC)

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11
Q

What are the symptoms of lung cancer?

A
Cough 
Weight loss
Dyspnoea
Chest pain 
Haemoptysis 
Bone pain 
Hoarseness 
Superior vena cava obstruction 
Pancoast syndrome 
Metastatic disease 
Non-metastatic effects
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12
Q

What are some lung cancer metastases?

A

Liver
Bone
Adrenal
Brain

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13
Q

What is the staging of NSCLC?

A

I- small tumour
II- moderate size tumour and/or local nodes
III- big tumour and/or non-local nodes
IV- non-nodal metastases

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14
Q

What is the treatment of NSCLC?

A

Surgery
Radiotherapy
Chemotherapy

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15
Q

What are paraneoplastic phenomena?

A

Group of rare disorders that are triggered by an abnormal immune system response to a cancerous tumour known as a ‘neoplasm’

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16
Q

What are some examples of paraneoplastic phenomena?

A
Hypercalcaemia 
Syndrome of inappropriate ADH secretion 
Neurological 
Haematological 
Hypertrophic osteoathropathy
Cushing’s syndrome