Respiratory histopathology

Question 1

What are the 7 descriptions for gross pathology?

Answer 1

Organ
Location 
Distribution 
Size/contours
Shape 
Colour 
Consistency

Question 2

What cells are found in acute inflammation?

Answer 2

Neutrophils and RBCs

Question 3

What cells are found in subacute inflammation?

Answer 3

Lymphocytes
Plasma cells
Eosinophils

Question 4

What cells are found in chronic inflammation?

Answer 4

Macrophages
Multinucleated giant cell
Fibroblasts

Question 5

Necrosis can often be seen with what other histological features?

Answer 5

Cell degeneration
Cell fragmentation
Protein rich debris

Question 6

Protein stains pink. What does light pink and dark pink suggest?

Answer 6

Light pink - oedema

Dark pink - fibrin

Question 7

How do bacteria appear histologically?

Answer 7

Finely granular basophilic clumps

Question 8

How do malignant tumours alter surrounding tissues?

Answer 8

Cause damage and necrosis
Cause haemorrhage
MENTION presence of inflammatory cells

Question 9

Fibroblasts have flattened nuclei. What does presence of fibroblasts suggest?

Answer 9

Repair

Question 10

What is a defining feature of a plasma cell?

Answer 10

Pale area north-east of nucleus

Question 11

What is the normal epithelium lining the URT?

Answer 11

Ciliated pseudo stratified columnar

Question 12

Which of the respiratory tract is most vulnerable to infection? Why?

Answer 12

Bronchioles

Have less cilia, therefore weaker mucociliary escalator clearance

Question 13

What should a normal lung look like histologically?

Answer 13

Alveolar spaces everywhere
Few bronchioles and blood vessels
Some alveolar macrophages

Question 14

How may an ulcer appear histologically? Where are these found?

Answer 14

Loss of ciliated columnar epithelium

From URT to bronchioles