Respiratory guidelines Flashcards
Asthma investigation - what do all adults get - what do children get
FeNO and spirometry with reversibility children only get FeNO if spirometry inconclusive
Astham investigation - diagnostic cutoffs reversibility FEV1/FVC ratio FeNO
12% reversibility (AND 200ml in adults) ratio of <0.7 FeNO >40ppb (>35 in children)
Asthma treatment escalation ADULTS
SABA + low dose ICS + LABA + LRTA or moderate dose ICS (stop LABA if not working) specialist
Asthma treatment escalation CHILDREN
SABA + very low dose ICS Step 2 (>5) = LABA or LTRA Step 2 (<5) = LTRA Step 3 = increase to low dose ICS. Add LABA/LRTA and stop LABA if not helpful specialist
Acute asthma attack categories
Life threatening = PEFR<33, silent chest, <92%, normal CO2 Acute severe = >110bpm, cant complete sentences, PEFR33-50, RR>25 Moderate = 50-75% PEFR
Acute asthma management standard escalated
standard - oxygen driven nebs (salbutamol and ipratropium) give ipra 4-6hourly, salbutamol back to back oral pred/ IV hydrocortisone for at least 5d escalated - 1st: IV magnesium - 2nd: IV aminophylline 3rd: IV salbutamol (rarely used), intubation etc
COPD Ix - if you suspect COPD what 3 things do you get
CXR (?mass), FBC (2’ polycythaemia), spirometry/reversibility testing
Grading of COPD cutoffs
All based on FEV1 Mild= >80 WITH symptoms and FEV1/FVC <0.7 mod = 50-80 severe = 30-50 very severe = <30
COPD treatment escalation
1) SABA or SAMA 2) asthmatic features = LABA+ICS; no asthmatic features = LABA/LAMA 3) oral theophylline
Antibiotic prophylaxis in COPD?
Azithromycin
Asthmatic features for COPD step 2???
1) previous history of asthma or atopy 2) eosinophilia 3) diurnal variation of PEFR >20% 4) FEV1 variation >400ml
When do you assess someone for LTOT if has COPD
FEV1 <30% (i.e. very severe) cyanosis/polycthaemia oedema/raised JVP
How do you assess someone for LTOT?
ABGs on two separate occasions
Based on the ABGs, when do you offer LTOT for COPD
pO2 <7.3 pO2 7.3-8 + oedema, polycythaemia, pul HTN
COPD exacerbation Mx
Nebulised bronchodilators and prednisolone 7-14d Abx if sign of infection –> amox + clari
CURB65 score and meaning
Confusion <=8/10 AMTS urea >7 RR >=20 BP <=90/60 65+ 0-1 = home with amox 5d (depending on CRP test) 2-3 = hospital with amox+clari 7d 4-5 = ITU with coamox/tazocin 7d
CRP point of care test in GP for penumonia
Helps you decide if Abx are needed if they score CURB0 >100 = yes 20-100 = delayed <20 = no
Abx guideline: - CAP - atypical CAP - HAP
CAP = amox atypical CAP = clarithromycin HAP depends on when it has occurred after admission (remember HAP is defined as at least 48 hours after admission): - if within first 5d = coamox, cefurox - if after 5th day of admission = taz, cipro, ceftaz
2ww lung cancer referral for CXR
40+ and any of: - cough, fatigue, SOB, pain, weight loss, anorexia need 2 of them if never smoked
2ww lung cancer referral for clinic straight away
40+ and haemoptysis or abnormal CXR
best Ix for lung Ca
CT (hence why you do it if CXR negative and youre still suspicious)
Difference between SCLC and NSCLC
SCLC not usually amenable to surgery, need chemo NSCLC usually amenable to surgery, both have radio
Idiopathic lung fibrosis - gold standard Ix - TLCO and spirometry
gold standard- high res CT - ground glass appearance
+ spirometry
+ CXR
restrictive picture on spirometry:
- FEV1 reduced
- FVC reduced
- FEV1/FVC ratio normal
TLCO is low
- low uptake of O2 from lungs to blood
definitive Tx for idiopathic lung fibrosis
lung transplant
Sarcoidosis useful tests (no diagnostic one)
raised ACE and ESR restrictive spirometry non-caseating granuloma formation bilateral hilar lymphadenpatphy upper zone fibrosis
Management of sarcoid
Don’t treat asymptomatic lymphadenopathy If Sx –> prednisolone
Interpretation of Mantoux test
injection of tuberculin into skin - screening for TB
If <6mm = no reaction, immunise If 6-15mm = medium reaction, ?previous TB or previous vaccination, don’t immunise If >15mm = big reaction, active TB
when do you use interferon gamma quantiferon gold test?
if Mantoux equivocal or positive If Mantoux inaccurate (sarcoid, military TB, lymphoma HIV)
Drugs for TB and SEs
Active = 2m RIPE and 4m RI Latent = 3m RIP or 6m IP Meningeal = 12m RIPE + steroids rifampicin = red piss and hepatitis isoniazid = peripheral neuropathy and hepatitis pyranzinamide = gout and hepatits ethambutol = optic neuritis
Pneumothorax Mx
Primary <2cm = clinic in 6/52!! >2cm OR BREATHLESS = aspirate and observe Secondary 0-1 = admit O2 observe 1-2 = aspirate >2 = chest drain
Wells score PE
0-4 is unlikely to be PE - D-dimer wihin 4 hrs
if D-Dimer +ve -> immediate CTPA
if D-Dimer -ve -> consider other diagnosis
. 5+ = CTPA` immediately or interim therapeutic anticoag while awaiting CTPA
do V/Q scan instead if contrast allergy or renal failure
PE most likely = 3 DVT present = 3 Recent immobilisation = 1.5 Previous DVT/PE = 1.5 Tachycardia >100 = 1.5 Haemoptysis = 1 Malignancy = 1
Well score DVT just the cutoff Mx based on that
0-1 is unlikely –> D-dimer to exclude 2+ is likely ==> USS leg within 4 hours. if cant get one within 4 hours, treat with LMWH assuming its there
DVT Wells score:
cancer: 1
calf swelling >= 3cm (measured 10cm below tibial tuberosity): 1
collateral superficial veins: 1
pitting oedema (in symptomatic leg): 1
swelling of entire leg: 1
localised tenderness along deep venous system: 1
paralysis, paresis, or recent cast immobilisation of legs: 1
recently bedridden >= 3 days, or major surgery in last 12 wks: 1
previous DVT : 1
alternative diagnosis at least as likely as DVT: -2
Do you start LMWH before the CTPA is back
yes because it usually takes a number of hours to get done
Tx of PE
haemodynamically unstable = thrombolysis (alteplase)
stable = DOAC (apixaban or rivaroxaban) or warfarin
if not suitable then: LMWH (e.g. enoxaparin) for 5d or until INR>2 for 2days whichever is longer.
start warfarin or NOAC witin 24 hours. if warfarin crossover with LMWH, if NOAC just give it 2 hours before dose and don’t carryover.
continue for at least 3 months in primary PE
3-6 months for active cancer
ARDS - how do you exclude thatit is cardiac in origin if unsure
pulmonary artery wedge pressure.
obstructive sleep apnoea Best Ix and other Ix
Sleep studies is best test Epworth sleepiness scale and multiple sleep latency test also used
Mx of obstructive sleep apnoea
If sleepiness in daytime –> CPAP at night If no sleepiness or CPAP not tolerate –> mandibular advancement device
pleural effusions and lights criteria
protein >35 = exudate protein <25 = transudate 25-35 use lights criteria exudate if: - pleural protein is >50% the serum protein - pleural LDH >60% serum LDH - pleural LDH >2/3rds NORMAL serum LDH
if pleural fluid is exudate?
contrast CT and send off sample to lab
if pleural fluid is purulent or has pH <7.2
chest tube
NG tube safety
pH <5.5 is happy days Otherwise need to do a CXR
NIV indications in COPD
any respiratory acidosis despite maximal therapy
when is an aspirate exudate
<25 protein = transudate >35 protein = exudate in between use lights criteria. Exudate if pleural fluid: - protein >50% serum protein - LDH >60% serum LDH - LDH >2/3rds normal serum LDH
should CO2 be normal in ABG in asthma
no it should be low - need referral to ITU if normal or high on ABG
safety triangle for pleural tap - pleural fluid aspirate, thoracocentesis
not below 5th intercostal space top is base of axilla posterior border of pectorals major anterior border of latissimus dorsi go on superior border of rib to avoid NV bundle
layers that you go through to do a pleural tap
- skin 2. epidermis 3. intercostal muscles 4. endothoracic fascia 5. parietal pleura
65yr M
progressive SOB
unilateral pleural effusion
pleural aspirate - what type of pleural effusion?
transudate
- low protein
- low LDH
causes of transudate
HF
liver cirrhosis
renal - nephrotic syndrome
ovarian - Meigs syndrome
sarcoidosis
thyroid myxoedema
causes of exudate pleural effusion
malignancy
infection
trauma
pulmonary embolus/ infarct
78
3 wk hx
dry cough
weight loss
breathlessness at rest
unilateral pleural effusion - type?
exudative
most likely due to cancer
monitoring of chest drain
bubbling
- normal in pneumothorax
abnormal in effusion - check for air leaks
swinging
- should occur with inspiration and expiration - if its not- blockage?
58yr M
routine abdo paracentesis
tender abdo
jaundice
confusion
fever
polymorphic neucleocyte count: 0.3
SA-AG = 15
SBP - Spontaneous bacterial peritonitis
indications for ascitic tap
diagnosis of new onset ascites
suspected SBP
therapeutic ( usually drainage/ paracentesis)
surface anatomy of ascitic tap
15cm lateral to umbilicus - left or right lower quadrant
avoid enlarged liver/ spleen and epigastric arteries
ascitic tap analysis
PMNs/neurophil > 250 = diagnostic of SBP
presentation of TB
suspected in anyone with cough for >3 wks
especially if accompanied by:
- haemoptysis
- SOB
- loss of appetite
- weight loss
- fever and sweating, especially night sweats
- fatigue and tiredness
- swollen glands
indication for CXR or referral to specialist for idiopathic pulmonary fibrosis
>45yrs
persisent breathlessness on exertion
persistent cough
bilateral inspiratory crackles
clubbing of fingers
normal spirometry or restrictive pattern
investigations if TB suspected
for active:
CXR/ CT + deep cough sputum sample (for micro, culture and histology)
for latent TB:
- Mantoux test - for close contacts with TB patients
- if Mantoux positive –> interferon-gamma release assay (quantaferon gold)
- if +ve: assess for active TB
- if -ve: treat for latent TB
radiological features of TB
primary TB:
- less than half of patients show radiological abnormalities
- there may be hilar lymph node enlargement
post-primary TB:
- patchy solid lesions
- cavitated solid lesions
- streaky fibrosis
- flecks of calcification
- solitary tuberculoma presenting as a coin lesion
- hilar node enlargement
Miliary TB:
- millet-sized nodules present throughout the lung fields
diagnosis
miliary TB
cough
fatigue
recently moved from developing country
diagnosis?
primary TB
upper zone consolidation
+ ipsilateral hilar enlargement
what is this showing in TB
healed primary TB
Ghon focus - TB has gone!