Respiratory Emergencies Flashcards
What is the 3rd leading cause of death of hospitalized pts in US?
Pulmonary embolism
*Also MC nonsurgical maternal death peripartum
What makes up Virchow’s triad?
- Venous stasis
- Vessel wall inflammation
- Hypercoagulability
What are RFs for pulmonary embolism?
“MOIST CAMELS”
- Malignancy
- Obesity
- Immobilization
- Surgery
- Trauma
- CHF
- Age > 40
- Mobility
- Estrogen excess (birth control)
- Long bone fx
- Smoker
What are signs & sx of a pulmonary embolism?
- Dyspnea
- Pleuritic CP
- Syncope
- LE pain/swelling
- Confusion/anxiety
- Hypoxia
What is the pulmonary embolism triad?
- Pleuritic CP
- SOB
- hemoptysis
What excludes significant pulmonary embolism if normal?
V/Q perfusion scan
But further dx testing required in 50-60%
What imaging studies are used for dx of pulmonary embolism? What is considered the test of choice?
- CT w/ contrast (dx test of choice*)
- Echo (evals ventricular dysfunction)
What is a venous compression u/s used for? What does it measure?
To evaluate venous system
- Measures groin distally
- Evaluates femoral & popliteal veins
Can ABG be used to exclude or dx pulmonary embolism?
No!
What does a D-dimer measure?
Fibrin degradation products
When is a D-dimer elevated or reduced?
- Elevated w/ CA, inflammation, infection, surgery, trauma, MI, pregnancy
- Reduced w/ warfarin, sx < 5 days, small clot
What labs can be elevated when a pulmonary embolism is present?
- Pro-BNP
- Troponin
What is the most common finding on EKG for pulmonary embolism?
Sinus tach
- S1Q3T3
Anticoagulation tx options for pulmonary embolism include what?
- Heparin
- Coumadin
- Lovenox
- Rivaroxaban
- If anticoag contraindicated –> Vena caval filter
What are indications of thrombolytic tx?
- Massive PE, hemodynamically unstable
- Massive DVT
- Large DVT w/ vascular compromise
What are contraindications for thrombolytic tx?
- Major bleeding within 6 mos
- Intracranial/spinal surgery or trauma within 2 mos
- Surgery within 10 days
- Peri/endocarditis
- Uncontrolled HTN
- Pregnancy
- Aneurysm
What agents are used in thrombolytic tx?
Streptokinase, urokinase, altelplase
What is embolectomy reserved for?
Massive PE w/ contraindications/unstable to fibrinolysis
What does catheter directed thrombolysis consist of?
Alteplase, followed by heparin infusion
What is the pathophysiology triad for asthma?
- Airway inflammation
- Obstruction to airflow
- Bronchial hyperesponsiveness
What is the clinical triad for asthma?
Dyspnea, wheezing, cough
What is the etiologies of COPD? (5)
- Tobacco use (MC)
- Occupational exposures
- Environmental exposures
- Alpha 1-antitrypsin deficiency
- IVDA
What are the signs & sx of COPD?
- Cough
- SOB
- Wheezing
- Tachypnea
- Cyanosis
What can you use to assess COPD?
- FEV1
- Pulse oximetry
- CXR (not routine)
- Blood tests (not routine)
What are the goals of tx for COPD?
- Reverse airflow obstruction
- Provide oxygenation
- Relieve inflammation
Pulmonary embolism: What is seen on CXR?
- 1/3 are normal
- Hamptons hump
- Westermarks sign
- Fleischner sign
What criteria is used to determine pulmonary embolism risk?
- Wells
- PERC
- Geneva
What pharmacological treatments are available for COPD?
- Beta agonists (Albuterol)
- Epinephrine
- Ipratropium bromide (give w/ beta agonist)
- Corticosteroids
- Magnesium sulfide (reserved for severe exacerbations)
- Heliox (reserved for severe rxns - peds)
- Theophylline (no longer recommended)
- Ketamine (sedation)
What are indications for a BiPAP for COPD?
- Cooperative pt
- Dyspnea
- Tachy
- Hypoxemia
What are contraindications for BiPAP?
- Need for emergent intubation
- Cardiac/resp arrest
- Inability to protect airway or clear secretions
- Decreased LOC
- Facial trauma or deformity
- Recent esophageal surgery
What are 4 BiPAP delivery methods?
- Facial mask
- Nasal mask
- Helmet
- Ventilator
What is the difference btwn inspiratory PAP (IPAP) & expiratory PAP (EPAP)?
Pressure support