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(Pharm) 01 > Respiratory Drugs > Flashcards

Respiratory Drugs Flashcards

1
Q

Dipenhydramine - mech

A

Reversible inhibitors of H1 histamine receptor, 1st gen

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2
Q

Dimenhydrinate - mech

A

Reversible inhibitors of H1 histamine receptor, 1st gen

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3
Q

Chlorpheniramine - mech

A

Reversible inhibitors of H1 histamine receptor, 1st gen

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4
Q

Loratidine - mech

A

Reversible inhibitors of H1 histamine receptor, 2nd gen

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5
Q

Fexofendaine - mech

A

Reversible inhibitors of H1 histamine receptor, 2nd gen

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6
Q

Desloratadine - mech

A

Reversible inhibitors of H1 histamine receptor, 2nd gen

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7
Q

Dipenhydramine - use

A

Allergy
Motion sickness
Sleep aid

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8
Q

Dimenhydrinate - use

A

Allergy
Motion sickness
Sleep aid

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9
Q

Chlorpheniramine - use

A

Allergy
Motion sickness
Sleep aid

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10
Q

Loratidine - use

A

Allergy

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11
Q

Fexofendaine - use

A

Allergy

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12
Q

Desloratadine - use

A

Allergy

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13
Q

Dipenhydramine - side fx (3)

A

Sedation
Antimuscarinic
Anti-a-adrenergic

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14
Q

Dimenhydrinate - side fx (3)

A

Sedation
Antimuscarinic
Anti-a-adrenergic

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15
Q

Chlorpheniramine - side fx (3)

A

Sedation
Antimuscarinic
Anti-a-adrenergic

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16
Q

Loratidine - side fx

A

Far less sedating than 1st gen because decreased entry to CNS

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17
Q

Fexofendaine - side fx

A

Far less sedating than 1st gen because decreased entry to CNS

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18
Q

Desloratadine - side fx

A

Far less sedating than 1st gen because decreased entry to CNS

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19
Q

Guaifenesin - use

A

Thins respiratory secretions, does not suppress cough reflex

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20
Q

N-acetylcysteine - use (2)

A

Mucolytic - loosen mucus plugs in CF

Antidote for acetaminophen overdose

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21
Q

N-acetylcysteine - mech

A

Disrupts disulfide bonds

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22
Q

Pseudoephedrine - mech

A

A agonists

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23
Q

Phenylephrine - mech

A

A agonists

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24
Q

Pseudoephedrine - use

A

Reduce hyperemia, edema, nasal congestion

Open obstructed Eustachian tubes

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25
Phenylephrine - use
Reduce hyperemia, edema, nasal congestion | Open obstructed Eustachian tubes
26
Pseudoephedrine - side fx
HTN | CNS stimulation/anxiety
27
Phenylephrine - side fx
HTN
28
Endothelin receptor antagonists (incl. bosentan) - use
For Pulm HTN: Decrease pulm vascular resistance
29
Endothelin receptor antagonists (incl. bosentan) - mech
Inhibiting endothelin-1 receptor
30
Endothelin receptor antagonists (incl. bosentan) - side fx
Hepatotoxicity (LFT)
31
PDE-5 Inhibitors (incl sildenafil) - use
Pulm HTN | Erectile Dysfn
32
PDE-5 Inhibitors (incl sildenafil) - mech
Inhibit cGMP PDE5 and prolong vasodilatory effect of NO
33
Prostacyclin analogs (incl epoprostenol, iloprost) - use
Pulm HTN
34
Prostacyclin analogs (incl epoprostenol, iloprost) - mech
Direct vasodilatory effect on pulm and systemic arterial vascular beds Inhibit platelet aggregation
35
Prostacyclin analogs (incl epoprostenol, iloprost) - side fx
Flushing | Jaw pain
36
Albuterol - use
Acute exacerbation of asthma
37
Albuterol - mech
B2 agonist relaxes bronchial smooth muscle
38
Salmeterol - use
Asthma prophylaxis, long acting
39
Salmeterol - mech
B2 agonist relaxes bronchial smooth muscle
40
Formoterol - use
Asthma prophylaxis, long acting
41
Formoterol - mech
B2 agonist relaxes bronchial smooth muscle
42
Salmeterol - side fx (2)
Tremor | Arrythmia
43
Formoterol - side fx (2)
Tremor | Arrythmia
44
Fluticasone - use
Asthma - first line
45
Budesonide - use
Asthma - first line
46
Fluticasone - mech
Steroid Inhibit synthesis of all cytokines Inactivate NF-KB, the transcription factor that induces production of TNF-a and other inflammatory agents
47
Budesonide - mech
Steroid Inhibit synthesis of all cytokines Inactivate NF-KB, the transcription factor that induces production of TNF-a and other inflammatory agents
48
Ipratroprium - use
Prevent bronchoconstriction in asthma | COPD
49
Ipratroprium - mech
Muscarinic antagonist that blocks muscarinic receptor competitively
50
Montelukast - use
For aspirin-induced asthma
51
Montelukast - mech
Antileukotreine that blocks leukotriene receptors (CysLT1)
52
Zafirlukast - use
For aspirin-induced asthma
53
Zafirlukast - mech
Antileukotreine that blocks leukotriene receptors (CysLT1)
54
Zileuton - use
Asthma
55
Zileuton - mech
Antileukotriene that inhibits 5-lipoxygenase pathway | Blocks conversion of arachidonic acid to leukotrienes
56
Zileuton - side fx
Hepatotoxic
57
Omalizumab - use
Allergic asthma resistant to inhaled steroids and long-acting B2 agonists
58
Omalizumab - mech
Monoclonal anti-IgE AB, binds unbound serum IgE and blocks binding to FcERI
59
Theophylline - use
Asthma
60
Theophylline - mech
Causes bronchodilation by inhibiting phosphodiesterase to increase cAMP levels due to decreased cAMP hydrolysis Metabolized by CYP 450 Blocks action of adenosin
61
Theophyilline - side fx
Narrow therapeutic window
62
Methacholine - use
Bronchial challenge test for asthma dx
63
Methacholine - mech
M3 agonist

(Pharm) 01 (23 decks)

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