Respiratory drugs Flashcards
What are my first gen H1 Blockers?
What are their uses?
What are their sides?
H1: Dephenhydramine, demenhydinate, chrlopheniramine
MOA: Allergy, motion sickness, sleep aid
Toxicity: Sedation and anti-muscarininc and anti-alpha-adrenergic: dry mought
*cause urinary retention in BPY!
What are my second Gen H1 blockers?
What are their uses?
What are their toxicity profiles?
Gen 2 H1: Loratadine, Fexofenadine, Desloratadine, (end in adine)
Uses are for ALLERGIES
Sides are FAR LESS then gen 1 bc they don’t enter the CNS
(good for old people)
What would i give someone to help cough shit out of lungs for THIN respiriatory secreations?
Guaifenesin: expectorant
What is the MOA and use for N-Acetlycycstein?
N-Acetcylcysteine: for mucolytic
loosens mucus plugs in CF pts and used as anti-dote for acetaminophen OD
also pre-tx people with renal issue for contract dye
This is and antitussive (antagonizes the NMDA glutamate R) and is a synthetic codeine analogue
What drug?
What side effect?
Drug = Dextromethorphan
OD then use Naloxone to tx it; mild abuse potential
What is the MOA of psuedopephedrine and phenlephrine?
What is the side effect we worry about?
Pseudophedrine and phenylephrine:
Sympathomimetic alpha AGONIST for nasal decongestions
will open open obstruted eustacian tubes
Pseudoephedrien allso used to make meth
Sides: HYPETENSION; make see CNA stimulation or anxiety
When would we tx someone with hyperbaric O2?
CO poisoning, decompression sickness, arterial gas emboli, gas gangrene, osteomyletis, acute MI
Sympathomimetic alpha agonist we can give someone with really bad edema or nasal congestions
Pseudoephedrine or phenyephrine
What mediates bronchocnx seen in asthmatics?
Inflammatory process
Parasympathetic tone
What B2 agonist are used to treat asthma?
Both lond and short acting?
Why do they work?
Albuterol (short acting) will b_ind B2 and RELAX the smooth msl_ at acute attack
Slameterol and Formetoerl: long acting–> they are prophy and are 2 agonists
Sides = tremor and arrythmia
This drug will cause bronchodialation by inhibiting phosphodiesteraes–> thus INCREASE cAMP lelves d/t decreased cAMP hydrolysis.
Theophylline: asthma drug; type of Methyxanthine
Old man takes Theophyline, what for? What’s MOA and what sides do we worry about?
Used for asthma
Bronchodialation by inhibiting phosphodiesterase–> Increase cAMP (not getting broken down)
LIMITED USE; very narrow TI : cardiotoxic and neurotoxic
Metabolized by C-P450 and blocks actions of adenosine
Competitive block of muscarinic receptors to prevent bronchoconstrction
Can be used to tx COPD as a LOOOOng acting musarining antagonists
Ipratorpium
Whats the MOA and use of Ipratropium?
competitive block of Muscarininc Receptotrs, thus no bronchoconstriction
Used for COPD (as is tiotropium)
***Muscarinin antagonist
What is the MOA of Beclamethasone, Fluticasone (corticosteroids)
inhiibt the Syntehtsi of virutually ALL cytokinse
Inactive NKkB (transcription facor that inducse produciton of TNF-Alpha as well as other inflammatory agents)
1st line for chronic asthma
These dudes block leukothriene Receptors and are GREAT for aspirin induced asthma
Montekulast and Zarfirlukast
Monoclonal IgE antibody; binds mostly unbound serum IgE and bloks binding to FCeRI
used for allergic ashma resistant to ihaled steorids and longs standing B2-agonits
OMalizumab
