Receptors Flashcards
What is the function of Alpha-1 Receptors
↑vascular sm msc cnx, mydriasis, ↑peripheral resist. ↑renin activity, ↑BP, ↑urine spincter tone
What is the fuction of the alpha-2 receptor
inhibtion or negative feedback
What is the function of Beta-1 receptors?
tachy, ↑HR ,↑lipolysis, ↑myocardial conx,
What is the function of Beta 2 receptors?
vasoD, ↓periph R, Bronchodilation, ↑lipolysis, ↑insulin, ↓uterin tone, ↑HR
a1. a2, b1, b2
Use; anaphylaxsis
Inhaled in croup- b2
Tx Hypotension
Epinephrine
a1 ,a2 ↓B1
Hypotension (from a1 to ↓renal perfusion)
1st line septic shock (too much vasoD) and cardiogenic shock
Norepinephrine
Low dose–>stims Dopa receptors
Medium–> b1 +b2:
High–>a1 + a2:
Dopamine:
Beta-1 in heart
↑HR and ↑ contractility
use for stress test and heart fail
Dobutamine
alpha-1
Pupil dialation and decongestant
Phenylephrine
Beta-2 stong and Beta-1
Asthma but Beta-1 cause tachycardia
Albuterol, levabuterol, salmeterol
Beta-2 and some Beta-1
Bronchospasm *can go subQ
Tocolysis (≠uterine cnx premature labor)
Terbutaline
a2: ↓Nepi secretion↓BP, hypertenstion.
Clonidine: As sedative
Out for malignant HTN, don’t stop fast = rebound
Methyldopa: HTN in pregnancy
Muscarinic: GCPR
M1:
M2 :
M3:
M1: enteric NS for rest and digest
M2 : ↓contractility and ↓HR @ SA node
M3: ↑bladder cnx, ↑ gut peristalsis, lacrimiation, boncocnx, miosis
Adrenergic: GCPR
a1:
a2:
b1:
b2:
a1: ↑sm msl contractility and vaso constrition
a2: autoregulaiton
b1: ↑HR, ↑contractility
b2: Bronchodilation
Dopamine Receptors (NT in brain)
D1:
D2:
D1: relax renal vascular sm mslc
D2: found in brain
Histamine: GCPR
H1:
H2:
H1: allergies; nasal secreation, mucus, pruitis, bronchocnx
H2: ↑gastric acid secreation (H2 blocker for acid reflux)
How do tyrosine kinase receptors work?
What uses tyrosine kinase receptors?
Tyrosine kinase path: can activate Phospholipase C –>DAG and IP3 OR RAS activating pathway
all the growth factors, Insulin, Prolactin, GH
Head and neck drain to the:
Lungs drain to :
Trachea and esophagus Drains to:
Head and neck drain to the: Cevical LN
Lungs drain to : Hilar LN
Trachea and esophagus Drains to: Mediastinal LN
Upper limb, breast, skin above belly button drain:
LIver/somtach/spleen/pancrease/upper dd drain to:
Lower dd, jejunum, ileum, colon to flexure drain:
Upper limb, breast, skin above belly button drain: Axillary LN
LIver/somtach/spleen/pancrease/upper dd drain to: Celiac LN
Lower dd, jejunum, ileum, colon to flexure drain: Superior Mesenteric
Colon from splenic flexure to upper rectum:
Lower recum to anal canal (above pecnate), bladder, vagina and prostate:
Testis/ovaries/kidnesy:
Colon from splenic flexure to upper rectum: Superficial inguinal
Lower recum to anal canal (above pecnate), bladder, vagina and prostate: Internal iliac
Testis/ovaries/kidnesy: para-aortic
Anal canal (below pectinate) skin below umbilicus:
Dorsolateral foot, posterior calf:
Anal canal (below pectinate) skin below umbilicus: Superifial inguinal
Dorsolateral foot, posterior calf: Popliteal
HLA-A3
Hemochormatosis
HLA- B27: PAIR
Psoriatic arthritis, Ankylosing spondylitis, arthritis of Inflammatory bowel disease, Reactive arthritis (formerly Reiter syndrome).
DQ2/DQ8
Celiacs
