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Step 1 Pharm > Receptors > Flashcards

Receptors Flashcards

1
Q

What is the function of Alpha-1 Receptors

A

↑vascular sm msc cnx, mydriasis, ↑peripheral resist. ↑renin activity, ↑BP, ↑urine spincter tone

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2
Q

What is the fuction of the alpha-2 receptor

A

inhibtion or negative feedback

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3
Q

What is the function of Beta-1 receptors?

A

tachy, ↑HR ,↑lipolysis, ↑myocardial conx,

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4
Q

What is the function of Beta 2 receptors?

A

vasoD, ↓periph R, Bronchodilation, ↑lipolysis, ↑insulin, ↓uterin tone, ↑HR

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5
Q

a1. a2, b1, b2

Use; anaphylaxsis

Inhaled in croup- b2

Tx Hypotension

A

Epinephrine

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6
Q

a1 ,a2 ↓B1

Hypotension (from a1 to ↓renal perfusion)

1st line septic shock (too much vasoD) and cardiogenic shock

A

Norepinephrine

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7
Q

Low dose–>stims Dopa receptors

Medium–> b1 +b2:

High–>a1 + a2:

A

Dopamine:

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8
Q

Beta-1 in heart

↑HR and ↑ contractility

use for stress test and heart fail

A

Dobutamine

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9
Q

alpha-1

Pupil dialation and decongestant

A

Phenylephrine

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10
Q

Beta-2 stong and Beta-1

Asthma but Beta-1 cause tachycardia

A

Albuterol, levabuterol, salmeterol

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11
Q

Beta-2 and some Beta-1

Bronchospasm *can go subQ

Tocolysis (≠uterine cnx premature labor)

A

Terbutaline

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12
Q

a2: ↓Nepi secretion↓BP, hypertenstion.

A

Clonidine: As sedative

Out for malignant HTN, don’t stop fast = rebound

Methyldopa: HTN in pregnancy

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13
Q

Muscarinic: GCPR

M1:

M2 :

M3:

A

M1: enteric NS for rest and digest

M2 : ↓contractility and ↓HR @ SA node

M3: ↑bladder cnx, ↑ gut peristalsis, lacrimiation, boncocnx, miosis

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14
Q

Adrenergic: GCPR

a1:

a2:

b1:

b2:

A

a1: ↑sm msl contractility and vaso constrition
a2: autoregulaiton
b1: ↑HR, ↑contractility
b2: Bronchodilation

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15
Q

Dopamine Receptors (NT in brain)

D1:

D2:

A

D1: relax renal vascular sm mslc

D2: found in brain

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16
Q

Histamine: GCPR

H1:

H2:

A

H1: allergies; nasal secreation, mucus, pruitis, bronchocnx

H2: ↑gastric acid secreation (H2 blocker for acid reflux)

17
Q

How do tyrosine kinase receptors work?

What uses tyrosine kinase receptors?

A

Tyrosine kinase path: can activate Phospholipase C –>DAG and IP3 OR RAS activating pathway

all the growth factors, Insulin, Prolactin, GH

18
Q

Head and neck drain to the:

Lungs drain to :

Trachea and esophagus Drains to:

A

Head and neck drain to the: Cevical LN

Lungs drain to : Hilar LN

Trachea and esophagus Drains to: Mediastinal LN

19
Q

Upper limb, breast, skin above belly button drain:

LIver/somtach/spleen/pancrease/upper dd drain to:

Lower dd, jejunum, ileum, colon to flexure drain:

A

Upper limb, breast, skin above belly button drain: Axillary LN

LIver/somtach/spleen/pancrease/upper dd drain to: Celiac LN

Lower dd, jejunum, ileum, colon to flexure drain: Superior Mesenteric

20
Q

Colon from splenic flexure to upper rectum:

Lower recum to anal canal (above pecnate), bladder, vagina and prostate:

Testis/ovaries/kidnesy:

A

Colon from splenic flexure to upper rectum: Superficial inguinal

Lower recum to anal canal (above pecnate), bladder, vagina and prostate: Internal iliac

Testis/ovaries/kidnesy: para-aortic

21
Q

Anal canal (below pectinate) skin below umbilicus:

Dorsolateral foot, posterior calf:

A

Anal canal (below pectinate) skin below umbilicus: Superifial inguinal

Dorsolateral foot, posterior calf: Popliteal

22
Q

HLA-A3

A

Hemochormatosis

23
Q

HLA- B27: PAIR

A

Psoriatic arthritis, Ankylosing spondylitis, arthritis of Inflammatory bowel disease, Reactive arthritis (formerly Reiter syndrome).

24
Q

DQ2/DQ8

A

Celiacs

25
Q

D2

D3

D4

D5

A

DR2: MS, hay fever, SLE, goodpasture

DR3: Diabetes Mellitus I, SLE, graves

DR4: Rheumatoid arthtisi, type DM

DR5: Pernisiouc aneia–B12 deficincy, Hashomoto

26
Q

Whats on T rge cells?

What does it realease?

A

T reg has CD3, CD4, CD25

releases IL-10 and TGF-B ANTI-inflammatory cytokines so immune system stays calm

Step 1 Pharm (15 decks)

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