Respiratory Disease in Childhood Flashcards
What does a lack of surfactant result in?
Atelectasis and impairment of gas exchange
What is the production of surfactant stimulated by?
Steroids
Respiratory distress syndrome is predominantly in preterm, what relationship does it have with gestation?
Inverse
What is there an increased incidence with IPPV, CPAP and ventilation?
Pneumothorax
What is the condition named where oxygen requirement is beyond 36 weeks corrected gestation plus evidence of pulmonary parenchymal disease onCXR?
Chronic lung disease
What does chronic lung disease generally follow?
RDS
What does a diaphragmatic hernia have associated with it=?
Pulmonary hypoplasia
Where are the two most common diaphragmatic hernias located?
Posterolateral (Bochdalek), left-sided
A 1 year old child presents with a prolonged history of cough, loose stools and failure to thrive - diagnosis?
CF
Anewborn infant with a raised immuno-reactive trypsin level on neonatal screening who is also found to be homozygous for the F508 deletion - diagnosis?
CF
Name a respiratory disease in childhood and adulthood that is autosomal recessive?
CF
What is the carrier incidence like for CF?
1 in 24 people
In CF what gene are the mutations found in?
CFTR gene
Is CF a multisystem disorder?
Yes
Give 4 differential diagnosises for CF?
- Immune deficiency
- Ciliary dyskinesia
- Asthma
- Kartagener’s immotile cilia syndrome - rare